| Literature DB >> 25170157 |
Miguel Carneiro1, Carl-Johan Rubin2, Federica Di Palma3,4, Nuno Ferrand1,5, Kerstin Lindblad-Toh2,3, Leif Andersson2,6,7, Frank W Albert8, Jessica Alföldi3, Alvaro Martinez Barrio2, Gerli Pielberg2, Nima Rafati2, Shumaila Sayyab6, Jason Turner-Maier3, Shady Younis2,9, Sandra Afonso1, Bronwen Aken10,11, Joel M Alves1,12, Daniel Barrell10,11, Gerard Bolet13, Samuel Boucher14, Hernán A Burbano8, Rita Campos1, Jean L Chang3, Veronique Duranthon15, Luca Fontanesi16, Hervé Garreau13, David Heiman3, Jeremy Johnson3, Rose G Mage17, Ze Peng18, Guillaume Queney19, Claire Rogel-Gaillard20, Magali Ruffier10,11, Steve Searle10, Rafael Villafuerte21, Anqi Xiong22, Sarah Young3, Karin Forsberg-Nilsson22, Jeffrey M Good8,23, Eric S Lander3.
Abstract
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.Entities:
Mesh：
Year: 2014 PMID： 25170157 PMCID： PMC5421586 DOI： 10.1126/science.1253714
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728