Literature DB >> 28811620

A new anthracycline-type metabolite from Streptomyces sp. NEAU-L3.

Chang Lu1, Yue Zhao1, Wei-Qi Jia1, Hui Zhang2, Huan Qi2, Wen-Sheng Xiang1, Ji-Dong Wang2, Xiang-Jing Wang1.   

Abstract

A new anthracycline-type metabolite, designated as tetracenoquinocin A (1), was isolated from the fermentation broth of Streptomyces sp. NEAU-L3. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. Compound 1 showed potent cytotoxic activity against three cancer cell lines (HepG2, A549, HCT-116) with IC50 values of 5.57, 24.30 and 20.82 μM, respectively.

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Year:  2017        PMID： 28811620     DOI： 10.1038/ja.2017.95

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  13 in total

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