| Literature DB >> 19575038 |
Jidong Wang1, Hui Zhang, Linping Ying, Chuanxi Wang, Nan Jiang, Yue Zhou, Haibin Wang, Hua Bai.
Abstract
With the aim of identifying more novel natural epothilone derivatives produced by the epothilones A and B producing strain Sorangium cellulosum strain So0157-2, a large-scale fermentation (5000 l) of the strain was carried out. As a result, five new epothilone variants (1-5) were isolated from the fermentation broth. Their structures were established as 3-alpha-D-arabinofuranosides of epothilones A (1), B (2), D (3), C(9) (4) and 8-demethyl epothilone A (5) by extensive NMR analysis and chemical methods. Bioassay results showed that compounds 1 and 2 had a weaker cytotoxic activity than did epothilone B.Entities:
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Year: 2009 PMID： 19575038 DOI： 10.1038/ja.2009.55
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649