Arttu O Lehtonen1, Ville L Langén2, Pauli J Puukka3, Mika Kähönen4, Markku S Nieminen5, Antti M Jula6, Teemu J Niiranen7. 1. Department of Health, National Institute for Health and Welfare, Turku, Finland; Department of Geriatrics, Turku City Hospital and University of Turku, Turku, Finland. Electronic address: arolle@utu.fi. 2. Department of Health, National Institute for Health and Welfare, Turku, Finland; Heart Centre, Turku University Central Hospital, Turku, Finland; Division of Medicine, Turku University Central Hospital, Turku, Finland. 3. Department of Health, National Institute for Health and Welfare, Turku, Finland. 4. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland. 5. Division of Cardiology, Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland. 6. Department of Health, National Institute for Health and Welfare, Turku, Finland; Division of Medicine, Turku University Central Hospital, Turku, Finland. 7. Department of Health, National Institute for Health and Welfare, Turku, Finland; National Heart, Lung, and Blood Institute's and Boston University's, Framingham Heart Study, Framingham, MA, USA.
Abstract
BACKGROUND: Scant data exist on incidence rates, correlates, and prognosis of electrocardiographic P-wave abnormalities in the general population. METHODS: We recorded ECG and measured conventional cardiovascular risk factors in 5667 Finns who were followed up for incident atrial fibrillation (AF). We obtained repeat ECGs from 3089 individuals 11years later. RESULTS: The incidence rates of prolonged P-wave duration, abnormal P terminal force (PTF), left P-wave axis deviation, and right P-wave axis deviation were 16.0%, 7.4%, 3.4%, and 2.2%, respectively. Older age and higher BMI were associated with incident prolonged P-wave duration and abnormal PTF (P≤0.01). Higher blood pressure was associated with incident prolonged P-wave duration and right P-wave axis deviation (P≤0.01). During follow-up, only prolonged P-wave duration predicted AF (multivariable-adjusted hazard ratio, 1.38; P=0.001). CONCLUSIONS: Modifiable risk factors associate with P-wave abnormalities that are common and may represent intermediate steps of atrial cardiomyopathy on a pathway leading to AF.
BACKGROUND: Scant data exist on incidence rates, correlates, and prognosis of electrocardiographic P-wave abnormalities in the general population. METHODS: We recorded ECG and measured conventional cardiovascular risk factors in 5667 Finns who were followed up for incident atrial fibrillation (AF). We obtained repeat ECGs from 3089 individuals 11years later. RESULTS: The incidence rates of prolonged P-wave duration, abnormal P terminal force (PTF), left P-wave axis deviation, and right P-wave axis deviation were 16.0%, 7.4%, 3.4%, and 2.2%, respectively. Older age and higher BMI were associated with incident prolonged P-wave duration and abnormal PTF (P≤0.01). Higher blood pressure was associated with incident prolonged P-wave duration and right P-wave axis deviation (P≤0.01). During follow-up, only prolonged P-wave duration predicted AF (multivariable-adjusted hazard ratio, 1.38; P=0.001). CONCLUSIONS: Modifiable risk factors associate with P-wave abnormalities that are common and may represent intermediate steps of atrial cardiomyopathy on a pathway leading to AF.
Authors: Tiia Istolahti; Antti Eranti; Heini Huhtala; Leo-Pekka Lyytikäinen; Mika Kähönen; Terho Lehtimäki; Markku Eskola; Ismo Anttila; Antti Jula; Antoni Bayés de Luna; Kjell Nikus; Jussi Hernesniemi Journal: Ann Med Date: 2020-03-14 Impact factor: 4.709
Authors: Ursula Moore; Roberto Fernandez-Torron; Marni Jacobs; Heather Gordish-Dressman; Jordi Diaz-Manera; Meredith K James; Anna G Mayhew; Elizabeth Harris; Michela Guglieri; Laura E Rufibach; Jia Feng; Andrew M Blamire; Pierre G Carlier; Simone Spuler; John W Day; Kristi J Jones; Diana X Bharucha-Goebel; Emmanuelle Salort-Campana; Alan Pestronk; Maggie C Walter; Carmen Paradas; Tanya Stojkovic; Madoka Mori-Yoshimura; Elena Bravver; Elena Pegoraro; Linda Pax Lowes; Jerry R Mendell; Kate Bushby; John Bourke; Volker Straub Journal: Muscle Nerve Date: 2022-03-05 Impact factor: 3.852