Literature DB >> 28806598

Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module.

Kiran Kumar Solingapuram Sai1, H Donald Gage2, Frankis Almaguel2, Bryan Neth3, Timothy M Hughes3, Sebastien Tremblay4, Christian-Alexandre Castellano4, Stephen C Cunnane4, Matthew J Jorgensen5, Suzanne Craft3, Akiva Mintz2.   

Abstract

We automated radiochemical synthesis of 1-[11C]acetoacetate in a commercially available radiochemistry module, TRASIS AllInOne by [11C]carboxylation of the corresponding enolate anion generated in situ from isopropenylacetate and MeLi, and purified by ion-exchange column resins.1-[11C]acetoacetate was synthesized with high radiochemical purity (95%) and specific activity (~ 66.6GBq/µmol, n = 30) with 35% radiochemical yield, decay corrected to end of synthesis. The total synthesis required ~ 16min. PET imaging studies were conducted with 1-[11C]acetoacetate in vervet monkeys to validate the radiochemical synthesis. Tissue uptake distribution was similar to that reported in humans.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Automation; Formulations; Ion-exchange column; Ketone metabolism; Non-Human primates; PET imaging

Year:  2017        PMID： 28806598      PMCID： PMC5612895          DOI： 10.1016/j.apradiso.2017.07.066

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  24 in total

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Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

2.  Dietary ketosis enhances memory in mild cognitive impairment.

Authors:  Robert Krikorian; Marcelle D Shidler; Krista Dangelo; Sarah C Couch; Stephen C Benoit; Deborah J Clegg
Journal:  Neurobiol Aging       Date:  2010-12-03       Impact factor: 4.673

3.  Age, sex and laterality effects on cerebral glucose metabolism in healthy adults.

Authors:  Mark W Willis; Terence A Ketter; Tim A Kimbrell; Mark S George; Peter Herscovitch; Aimee L Danielson; Brenda E Benson; Robert M Post
Journal:  Psychiatry Res       Date:  2002-02-15       Impact factor: 3.222

4.  beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats.

Authors:  P B Bianchi; A T Davis
Journal:  J Nutr       Date:  1996-11       Impact factor: 4.798

5.  PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis.

Authors:  M'hamed Bentourkia; Sébastien Tremblay; Fabien Pifferi; Jacques Rousseau; Roger Lecomte; Stephen Cunnane
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-01-27       Impact factor: 4.310

6.  Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.

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Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

7.  The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.

Authors:  Maggie Roy; Scott Nugent; Jennifer Tremblay-Mercier; Sébastien Tremblay; Alexandre Courchesne-Loyer; Jean-François Beaudoin; Luc Tremblay; Maxime Descoteaux; Roger Lecomte; Stephen C Cunnane
Journal:  Brain Res       Date:  2012-10-09       Impact factor: 3.252

Review 8.  Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate.

Authors:  Fabien Pifferi; Sébastien Tremblay; Mélanie Plourde; Jennifer Tremblay-Mercier; M'hamed Bentourkia; Stephen C Cunnane
Journal:  Epilepsia       Date:  2008-11       Impact factor: 5.864

9.  Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose.

Authors:  Sébastien Tremblay; René Ouellet; Serge Rodrigue; Réjean Langlois; François Bénard; Stephen C Cunnane
Journal:  Appl Radiat Isot       Date:  2007-03-28       Impact factor: 1.513

10.  An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography.

Authors:  G H Prenen; K G Go; F Zuiderveen; A M Paans; W Vaalburg
Journal:  Int J Rad Appl Instrum A       Date:  1990
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  3 in total

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Review 2.  Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.

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3.  Gut-derived acetate promotes B10 cells with antiinflammatory effects.

Authors:  C I Daïen; J Tan; R Audo; J Mielle; L E Quek; J R Krycer; A Angelatos; M Duraes; G Pinget; D Ni; R Robert; M J Alam; M C B Amian; F Sierro; A Parmar; G Perkins; S Hoque; A K Gosby; S J Simpson; R V Ribeiro; C R Mackay; L Macia
Journal:  JCI Insight       Date:  2021-04-08
  3 in total

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