Literature DB >> 1963420

An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography.

G H Prenen1, K G Go, F Zuiderveen, A M Paans, W Vaalburg.   

Abstract

1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after injection into adult Wistar rats and cats was investigated by PET. When the tracer was injected into cats, 3 weeks after inflicting a unilateral freezing lesion upon the brain, accumulation of 1-11C-acetoacetic acid in the ipsilateral brain hemisphere was observed.

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Year:  1990        PMID： 1963420     DOI： 10.1016/0883-2889(90)90208-x

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN： 0883-2889


  3 in total

1.  Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.

Authors:  Ubaldo E Martinez-Outschoorn; Marco Prisco; Adam Ertel; Aristotelis Tsirigos; Zhao Lin; Stephanos Pavlides; Chengwang Wang; Neal Flomenberg; Erik S Knudsen; Anthony Howell; Richard G Pestell; Federica Sotgia; Michael P Lisanti
Journal:  Cell Cycle       Date:  2011-04-15       Impact factor: 4.534

2.  Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module.

Authors:  Kiran Kumar Solingapuram Sai; H Donald Gage; Frankis Almaguel; Bryan Neth; Timothy M Hughes; Sebastien Tremblay; Christian-Alexandre Castellano; Stephen C Cunnane; Matthew J Jorgensen; Suzanne Craft; Akiva Mintz
Journal:  Appl Radiat Isot       Date:  2017-08-02       Impact factor: 1.513

3.  Metabolomics in bladder cancer: a systematic review.

Authors:  Yidong Cheng; Xiao Yang; Xiaheng Deng; Xiaolei Zhang; Pengchao Li; Jun Tao; Chao Qin; Jifu Wei; Qiang Lu
Journal:  Int J Clin Exp Med       Date:  2015-07-15
  3 in total

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