Literature DB >> 28806132

Plight of the pore polar bar(rier).

Jerod S Denton1,2, Sujay V Kharade1.   

Abstract

Keywords:  Kir1.1; Kir7.1; drug discovery; high-throughput screening; inward rectifier potassium channel; mutagenesis; patch clamp electrophysiology; pharmacology; small-molecule

Mesh：

Substances：

Year:  2017        PMID： 28806132      PMCID： PMC5786191          DOI： 10.1080/19336950.2017.1367234

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


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  7 in total

1.  Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.

Authors:  Sujay V Kharade; Jonathan H Sheehan; Eric E Figueroa; Jens Meiler; Jerod S Denton
Journal:  Mol Pharmacol       Date:  2017-06-15       Impact factor: 4.436

2.  High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.

Authors:  L Michelle Lewis; Gautam Bhave; Brian A Chauder; Sreedatta Banerjee; Katharina A Lornsen; Rey Redha; Katherine Fallen; Craig W Lindsley; C David Weaver; Jerod S Denton
Journal:  Mol Pharmacol       Date:  2009-08-25       Impact factor: 4.436

Review 3.  Novel diuretic targets.

Authors:  Jerod S Denton; Alan C Pao; Merritt Maduke
Journal:  Am J Physiol Renal Physiol       Date:  2013-07-17

4.  ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

Authors:  Daniel R Swale; Haruto Kurata; Sujay V Kharade; Jonathan Sheehan; Rene Raphemot; Karl R Voigtritter; Eric E Figueroa; Jens Meiler; Anna L Blobaum; Craig W Lindsley; Corey R Hopkins; Jerod S Denton
Journal:  ACS Chem Neurosci       Date:  2016-05-24       Impact factor: 4.418

Review 5.  Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.

Authors:  Daniel R Swale; Sujay V Kharade; Jerod S Denton
Journal:  Curr Opin Pharmacol       Date:  2013-11-26       Impact factor: 5.547

6.  G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Authors:  Masoud Ghamari-Langroudi; Gregory J Digby; Julien A Sebag; Glenn L Millhauser; Rafael Palomino; Robert Matthews; Taneisha Gillyard; Brandon L Panaro; Iain R Tough; Helen M Cox; Jerod S Denton; Roger D Cone
Journal:  Nature       Date:  2015-01-19       Impact factor: 49.962

7.  The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.

Authors:  Conor McCloskey; Cara Rada; Elizabeth Bailey; Samantha McCavera; Hugo A van den Berg; Jolene Atia; David A Rand; Anatoly Shmygol; Yi-Wah Chan; Siobhan Quenby; Jan J Brosens; Manu Vatish; Jie Zhang; Jerod S Denton; Michael J Taggart; Catherine Kettleborough; David Tickle; Jeff Jerman; Paul Wright; Timothy Dale; Srinivasan Kanumilli; Derek J Trezise; Steve Thornton; Pamela Brown; Roberto Catalano; Nan Lin; Sarah K England; Andrew M Blanks
Journal:  EMBO Mol Med       Date:  2014-09       Impact factor: 12.137
  7 in total
  2 in total

Review 1.  Inward rectifier potassium (Kir) channels in the retina: living our vision.

Authors:  Katie M Beverley; Bikash R Pattnaik
Journal:  Am J Physiol Cell Physiol       Date:  2022-08-01       Impact factor: 5.282

2.  Kir7.1 disease mutant T153I within the inner pore affects K+ conduction.

Authors:  Katie M Beverley; Pawan K Shahi; Meha Kabra; Qianqian Zhao; Joseph Heyrman; Jack Steffen; Bikash R Pattnaik
Journal:  Am J Physiol Cell Physiol       Date:  2022-05-18       Impact factor: 5.282
  2 in total

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