Literature DB >> 24721648

Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.

Daniel R Swale1, Sujay V Kharade1, Jerod S Denton2.   

Abstract

Inward rectifier potassium (Kir) channels play fundamental roles in cardiac and renal function and may represent unexploited drug targets for cardiovascular diseases. However, the limited pharmacology of Kir channels has slowed progress toward exploring their integrative physiology and therapeutic potential. Here, we review recent progress toward developing the small-molecule pharmacology for Kir2.x, Kir4.1, and Kir7.1 and discuss common mechanistic themes that may help guide future Kir channel-directed drug discovery efforts.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24721648      PMCID： PMC4097192          DOI： 10.1016/j.coph.2013.11.002

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  57 in total

1.  Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK.

Authors:  D B Simon; F E Karet; J Rodriguez-Soriano; J H Hamdan; A DiPietro; H Trachtman; S A Sanjad; R P Lifton
Journal:  Nat Genet       Date:  1996-10       Impact factor: 38.330

2.  Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

Authors:  Scott Pegan; Christine Arrabit; Wei Zhou; Witek Kwiatkowski; Anthony Collins; Paul A Slesinger; Senyon Choe
Journal:  Nat Neurosci       Date:  2005-02-20       Impact factor: 24.884

3.  Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction.

Authors:  Tania Ferrer; Daniela Ponce-Balbuena; Angélica López-Izquierdo; Ivan A Aréchiga-Figueroa; Teun P de Boer; Marcel A G van der Heyden; José A Sánchez-Chapula
Journal:  Eur J Pharmacol       Date:  2011-06-06       Impact factor: 4.432

4.  Primary structure and functional properties of an epithelial K channel.

Authors:  H Zhou; S S Tate; L G Palmer
Journal:  Am J Physiol       Date:  1994-03

Review 5.  Multiplicity of effectors of the cardioprotective agent, diazoxide.

Authors:  William A Coetzee
Journal:  Pharmacol Ther       Date:  2013-06-19       Impact factor: 12.310

6.  Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.

Authors:  Ricardo Caballero; Pablo Dolz-Gaitón; Ricardo Gómez; Irene Amorós; Adriana Barana; Marta González de la Fuente; Lourdes Osuna; Juan Duarte; Angelica López-Izquierdo; Ignacio Moraleda; Enrique Gálvez; José Antonio Sánchez-Chapula; Juan Tamargo; Eva Delpón
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

7.  Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.

Authors:  Ute I Scholl; Murim Choi; Tiewen Liu; Vincent T Ramaekers; Martin G Häusler; Joanne Grimmer; Sheldon W Tobe; Anita Farhi; Carol Nelson-Williams; Richard P Lifton
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-16       Impact factor: 11.205

Review 8.  Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

Authors:  M A G van der Heyden; A Stary-Weinzinger; J A Sanchez-Chapula
Journal:  Curr Mol Med       Date:  2013-09       Impact factor: 2.222

9.  Spermine and spermidine as gating molecules for inward rectifier K+ channels.

Authors:  E Ficker; M Taglialatela; B A Wible; C M Henley; A M Brown
Journal:  Science       Date:  1994-11-11       Impact factor: 47.728

10.  Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.

Authors:  David A Calhoun; Daniel Jones; Stephen Textor; David C Goff; Timothy P Murphy; Robert D Toto; Anthony White; William C Cushman; William White; Domenic Sica; Keith Ferdinand; Thomas D Giles; Bonita Falkner; Robert M Carey
Journal:  Hypertension       Date:  2008-04-07       Impact factor: 10.190
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  12 in total

1.  Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.

Authors:  Sujay V Kharade; Jonathan H Sheehan; Eric E Figueroa; Jens Meiler; Jerod S Denton
Journal:  Mol Pharmacol       Date:  2017-06-15       Impact factor: 4.436

2.  Plight of the pore polar bar(rier).

Authors:  Jerod S Denton; Sujay V Kharade
Journal:  Channels (Austin)       Date:  2017-08-25       Impact factor: 2.581

Review 3.  Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.

Authors:  Leszek Kubin
Journal:  Compr Physiol       Date:  2016-09-15       Impact factor: 9.090

4.  VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels.

Authors:  Samantha J McClenahan; Caitlin N Kent; Sujay V Kharade; Elena Isaeva; Jade C Williams; Changho Han; Andrew Terker; Robert Gresham; Roman M Lazarenko; Emily L Days; Ian M Romaine; Joshua A Bauer; Olivier Boutaud; Gary A Sulikowski; Raymond Harris; C David Weaver; Alexander Staruschenko; Craig W Lindsley; Jerod S Denton
Journal:  Mol Pharmacol       Date:  2022-03-03       Impact factor: 4.054

5.  Computational and functional analyses of a small-molecule binding site in ROMK.

Authors:  Daniel R Swale; Jonathan H Sheehan; Sreedatta Banerjee; Afeef S Husni; Thuy T Nguyen; Jens Meiler; Jerod S Denton
Journal:  Biophys J       Date:  2015-03-10       Impact factor: 4.033

6.  Inhibition of Kir4.1 potassium channels by quinacrine.

Authors:  Leticia G Marmolejo-Murillo; Iván A Aréchiga-Figueroa; Meng Cui; Eloy G Moreno-Galindo; Ricardo A Navarro-Polanco; José A Sánchez-Chapula; Tania Ferrer; Aldo A Rodríguez-Menchaca
Journal:  Brain Res       Date:  2017-03-11       Impact factor: 3.252

7.  ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

Authors:  Daniel R Swale; Haruto Kurata; Sujay V Kharade; Jonathan Sheehan; Rene Raphemot; Karl R Voigtritter; Eric E Figueroa; Jens Meiler; Anna L Blobaum; Craig W Lindsley; Corey R Hopkins; Jerod S Denton
Journal:  ACS Chem Neurosci       Date:  2016-05-24       Impact factor: 4.418

8.  Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.

Authors:  Sujay V Kharade; Haruto Kurata; Aaron M Bender; Anna L Blobaum; Eric E Figueroa; Amanda Duran; Meghan Kramer; Emily Days; Paige Vinson; Daniel Flores; Lisa M Satlin; Jens Meiler; C David Weaver; Craig W Lindsley; Corey R Hopkins; Jerod S Denton
Journal:  Mol Pharmacol       Date:  2018-06-12       Impact factor: 4.436

Review 9.  Beneficial Effects of High Potassium: Contribution of Renal Basolateral K+ Channels.

Authors:  Alexander Staruschenko
Journal:  Hypertension       Date:  2018-04-30       Impact factor: 10.190

Review 10.  Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.

Authors:  C David Weaver; Jerod S Denton
Journal:  Am J Physiol Cell Physiol       Date:  2021-04-07       Impact factor: 5.282
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