Diego Marcos-Pérez1, María Sánchez-Flores1, Ana Maseda2, Laura Lorenzo-López2, José C Millán-Calenti2, Barbara Strasser3, Johanna M Gostner3, Dietmar Fuchs3, Eduardo Pásaro4, Vanessa Valdiglesias5, Blanca Laffon4. 1. DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coruña, A Coruña, Spain; Department of Cell and Molecular Biology, Universidade da Coruña, A Coruña, Spain. 2. Gerontology Research Group, Universidade da Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, A Coruña, Spain. 3. Biocenter, Innsbruck Medical University, Innsbruck, Austria. 4. DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coruña, A Coruña, Spain. 5. DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coruña, A Coruña, Spain. Electronic address: vvaldiglesias@udc.es.
Abstract
BACKGROUND: Frailty is a multidimensional syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalization, and death in the elderly. It is based on the interplay of physiological, psychological, social, and environmental factors. OBJECTIVES: Because aging involves a detrimental immune response, this work aimed to assess the possible role of chronic low-grade immune stimulation on frailty status in the elderly. METHODS: Biomarkers involved in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways (namely neopterin, tryptophan, kynurenine, phenylalanine, tyrosine, and nitrite) were analyzed in a population of Spanish older adults aged 65 years and above, and their relationships with frailty status were evaluated. RESULTS: Significant increases in neopterin levels, kynurenine/tryptophan ratio, and phenylalanine/tyrosine ratio, and significant decreases in tryptophan, nitrite and tyrosine concentrations in frail individuals compared with nonfrail persons were obtained. Significant correlations were also observed between immune biomarkers, indicating they change in parallel, thus, pointing to interrelated causes. Besides, reference ranges for a number of immune biomarkers in the population of robust older adults were established for the first time. CONCLUSIONS: Results obtained in the present study are consistent with the idea that frailty status in the elderly is associated with an additional degree of immune stimulation, manifested in a more intense disturbance of indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I pathways than in nonfrail or prefrail older adults.
BACKGROUND: Frailty is a multidimensional syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalization, and death in the elderly. It is based on the interplay of physiological, psychological, social, and environmental factors. OBJECTIVES: Because aging involves a detrimental immune response, this work aimed to assess the possible role of chronic low-grade immune stimulation on frailty status in the elderly. METHODS: Biomarkers involved in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways (namely neopterin, tryptophan, kynurenine, phenylalanine, tyrosine, and nitrite) were analyzed in a population of Spanish older adults aged 65 years and above, and their relationships with frailty status were evaluated. RESULTS: Significant increases in neopterin levels, kynurenine/tryptophan ratio, and phenylalanine/tyrosine ratio, and significant decreases in tryptophan, nitrite and tyrosine concentrations in frail individuals compared with nonfrail persons were obtained. Significant correlations were also observed between immune biomarkers, indicating they change in parallel, thus, pointing to interrelated causes. Besides, reference ranges for a number of immune biomarkers in the population of robust older adults were established for the first time. CONCLUSIONS: Results obtained in the present study are consistent with the idea that frailty status in the elderly is associated with an additional degree of immune stimulation, manifested in a more intense disturbance of indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I pathways than in nonfrail or prefrail older adults.
Authors: Li Meng; Hong Shi; Da-Guang Wang; Jing Shi; Wen-Bin Wu; Ya-Min Dang; Guo-Qing Fan; Ji Shen; Pu-Lin Yu; Jun Dong; Rui-Yue Yang; Huan Xi Journal: Front Med (Lausanne) Date: 2022-01-28
Authors: Diego Marcos-Pérez; María Sánchez-Flores; Ana Maseda; Laura Lorenzo-López; José C Millán-Calenti; Johanna M Gostner; Dietmar Fuchs; Eduardo Pásaro; Blanca Laffon; Vanessa Valdiglesias Journal: Front Immunol Date: 2018-05-16 Impact factor: 7.561
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Authors: Lijie Zhai; April Bell; Erik Ladomersky; Kristen L Lauing; Lakshmi Bollu; Jeffrey A Sosman; Bin Zhang; Jennifer D Wu; Stephen D Miller; Joshua J Meeks; Rimas V Lukas; Eugene Wyatt; Lynn Doglio; Gary E Schiltz; Robert H McCusker; Derek A Wainwright Journal: Front Immunol Date: 2020-06-16 Impact factor: 8.786
Authors: Armanda Teixeira-Gomes; Blanca Laffon; Vanessa Valdiglesias; Johanna M Gostner; Thomas Felder; Carla Costa; Joana Madureira; Dietmar Fuchs; João Paulo Teixeira; Solange Costa Journal: Antioxidants (Basel) Date: 2021-12-10