Magda Mohamad1, Somaia Ebeid2, Mohamed Shawky Khater2, Mohamad Alsadany2. 1. Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 2. Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. METHODS: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants. RESULTS: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio. CONCLUSION: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated INF-γ and neopterin and decreased with elevated NO levels.
BACKGROUND: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. METHODS: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants. RESULTS: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio. CONCLUSION: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated INF-γ and neopterin and decreased with elevated NO levels.
Authors: Imrich Blasko; Gabriele Knaus; Elisabeth Weiss; Georg Kemmler; Christiana Winkler; Gerda Falkensammer; Andrea Griesmacher; Reinhard Würzner; Josef Marksteiner; Dietmar Fuchs Journal: J Psychiatr Res Date: 2006-03-20 Impact factor: 4.791
Authors: B Vellas; H Villars; G Abellan; M E Soto; Y Rolland; Y Guigoz; J E Morley; W Chumlea; A Salva; L Z Rubenstein; P Garry Journal: J Nutr Health Aging Date: 2006 Nov-Dec Impact factor: 4.075