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Literature DB >> 2878870

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library.

L Bufton, T K Mohandas, R E Magenis, R Sheehy, R K Bestwick, M Litt.

Abstract

A cosmid library was constructed from genomic DNA of a human-mouse somatic cell hybrid containing an 11q-16q translocation chromosome as the only human DNA. Cosmids with human inserts were prehybridized with total human DNA and were screened to find probes that revealed highly polymorphic loci. From one such cosmid, CF33-79, a single-copy subclone was isolated which revealed an insertion/deletion polymorphism with at least 11 alleles and a PIC of 0.77. Using a somatic cell hybrid mapping panel, the subclone was mapped to chromosome 16. By in situ hybridization with the entire cosmid used as a probe, chromosomal localization was shown at 16q22----24.

Entities: Species

Mesh：

Substances：
Genetic Markers
DNA

Year: 1986 PMID： 2878870 DOI： 10.1007/bf00280499

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

30 in total

1. A highly polymorphic locus in human DNA revealed by probes from cosmid 1-5 maps to chromosome 2q35----37.

Authors: M Litt; G A Bruns; R Sheehy; R E Magenis
Journal: Am J Hum Genet Date: 1986-03 Impact factor: 11.025

2. Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

Authors: G I Bell; J H Karam; W J Rutter
Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

3. Mapping studies on human mitochondrial glutamate oxaloacetate transaminase.

Authors: S J Jeremiah; S Povey; M W Burley; C Kielty; M Lee; G Spowart; G Corney; P J Cook
Journal: Ann Hum Genet Date: 1982-05 Impact factor: 1.670

4. Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q.

Authors: N E Buroker; R E Magenis; K Weliky; G Bruns; M Litt
Journal: Hum Genet Date: 1986-01 Impact factor: 4.132

5. A polymorphic locus on the long arm of chromosome 20 defined by two probes from a single cosmid.

Authors: M Litt; R Sheehy; G A Bruns; R E Magenis
Journal: Hum Genet Date: 1986-08 Impact factor: 4.132

6. Assignment of the gene for adenine phosphoribosyltransferase to human chromosome 16 by mouse-human somatic cell hybridization.

Authors: J A Tischfield; F H Ruddle
Journal: Proc Natl Acad Sci U S A Date: 1974-01 Impact factor: 11.205

7. Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.

Authors: M M Le Beau; M O Diaz; M Karin; J D Rowley
Journal: Nature Date: 1985 Feb 21-27 Impact factor: 49.962

Review 8. Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Authors: D Botstein; R L White; M Skolnick; R W Davis
Journal: Am J Hum Genet Date: 1980-05 Impact factor: 11.025

9. Regional assignment of genes for human alpha-globin and phosphoglycollate phosphatase to the short arm of chromosome 16.

Authors: H P Koeffler; R S Sparkes; H Stang; T Mohandas
Journal: Proc Natl Acad Sci U S A Date: 1981-11 Impact factor: 11.205

10. Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors: L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal: Science Date: 1985-11-29 Impact factor: 47.728

16 in total

1. Genetic linkage map of 46 DNA markers on human chromosome 16.

Authors: T P Keith; P Green; S T Reeders; V A Brown; P Phipps; A Bricker; K Falls; K S Rediker; J A Powers; C Hogan
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

2. A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Déjérine) muscular dystrophy: linkage analysis of six autosomes.

Authors: S J Jacobsen; E S Diala; B V Dorsey; M B Rising; R Graveline; K Falls; P Schultz; C Hogan; K Rediker; C D'Amico
Journal: Am J Hum Genet Date: 1990-09 Impact factor: 11.025

3. Population genetics of the highly polymorphic locus D16S7 and its use in paternity evaluation.

Authors: J A Chimera; C R Harris; M Litt
Journal: Am J Hum Genet Date: 1989-12 Impact factor: 11.025

4. Molecular genetics of human chromosome 16.

Authors: G R Sutherland; S Reeders; V J Hyland; D F Callen; A Fratini; J C Mulley
Journal: J Med Genet Date: 1987-08 Impact factor: 6.318

5. A hypervariable repeated sequence on human chromosome 1p36.

Authors: N Buroker; R Bestwick; G Haight; R E Magenis; M Litt
Journal: Hum Genet Date: 1987-10 Impact factor: 4.132

6. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

Authors: H Tsuda; W D Zhang; Y Shimosato; J Yokota; M Terada; T Sugimura; T Miyamura; S Hirohashi
Journal: Proc Natl Acad Sci U S A Date: 1990-09 Impact factor: 11.205

7. Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.

Authors: J T Pang; S E Lloyd; C Wooding; B Farren; B Pottinger; B Harding; S E Leigh; M A Pook; F J Benham; G T Gillett; R T Taggart; R V Thakker
Journal: Hum Genet Date: 1996-06 Impact factor: 4.132