Youssef M Roman1, Kathleen A Culhane-Pera2, Jeremiah Menk3, Robert J Straka1. 1. Department of Experimental & Clinical Pharmacology, University of Minnesota College of Pharmacy, MN 55455, USA. 2. West Side Community Health Services, Saint Paul, MN 55107, USA. 3. Center of Translational Science Institute, Biostatistical Design & Analysis Center, University of Minnesota, MN 55455, USA.
Abstract
AIM: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to fivefold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB). METHODS: In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1). RESULTS: The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence. CONCLUSION: Hyperuricemia risk alleles are more prevalent in the Hmong than CEU and HB.
AIM: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to fivefold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB). METHODS: In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1). RESULTS: The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence. CONCLUSION:Hyperuricemia risk alleles are more prevalent in the Hmong than CEU and HB.
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