The Daniel K. Inouye College of Pharmacy Scripts: Perspectives on the Epidemiology of Gout and Hyperuricemia.

Gout is the most common inflammatory arthritic condition affecting more men than women. Hyperuricemia and the deposition of urate crystals into the joints are the hallmarks of gout. The prevalence of gout and hyperuricemia is rising in the United States and world-wide possibly due to the aging population, comorbidities, and other lifestyle factors. Gout and serum uric acid (SUA) levels are highly heritable, underscoring the role of genetics on disease risk and possibly the racial disparities in gout prevalence. However, high consumption of high fructose corn syrup, alcohol, select dietary lifestyles, and use of diuretics are associated with higher SUA levels and increased risk for developing gout. Adopting healthy diet and lifestyle modifications can lower SUA levels. Nonetheless, diet-based approaches for the management of gout should remain a secondary approach to urate lowering therapy.