Literature DB >> 2877934

Linkage relationships of the insulin receptor gene with the complement component 3, LDL receptor, apolipoprotein C2 and myotonic dystrophy loci on chromosome 19.

D J Shaw, A L Meredith, J D Brook, M Sarfarzi, H G Harley, S M Huson, G I Bell, P S Harper.   

Abstract

Myotonic dystrophy is associated with disturbances in the insulin response, possibly due to an abnormality of the insulin receptor. Both the myotonic dystrophy (DM) and insulin receptor (INSR) genes are on chromosome 19. Using a cloned gene probe for INSR, we have studied its linkage relationships with the DM locus and other chromosome 19 markers. The results show that INSR is not closely linked to DM, but is located very close to C3, in the region 19pter-19p13.2. This implies that the basic genetic defect which causes DM is not directly responsible for the disturbed insulin response in these patients.

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Year:  1986        PMID： 2877934     DOI： 10.1007/bf00282546

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  13 in total

1.  Report of the Committee on the Genetic Constitution of Chromosomes 17, 18 and 19.

Authors:  S Naylor; J M Lalouel; D J Shaw
Journal:  Cytogenet Cell Genet       Date:  1985

2.  Genetic linkage between the loci for myotonic dystrophy and peptidase D.

Authors:  T O'Brien; S Ball; M Sarfarazi; P S Harper; E B Robson
Journal:  Ann Hum Genet       Date:  1983-05       Impact factor: 1.670

3.  Localisation of genetic markers and orientation of the linkage group on chromosome 19.

Authors:  J D Brook; D J Shaw; L Meredith; G A Bruns; P S Harper
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.

Authors:  A Ullrich; J R Bell; E Y Chen; R Herrera; L M Petruzzelli; T J Dull; A Gray; L Coussens; Y C Liao; M Tsubokawa
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

5.  Rsa1 polymorphism at the insulin receptor locus (INSR) on chromosome 19.

Authors:  D J Shaw; G I Bell
Journal:  Nucleic Acids Res       Date:  1985-12-09       Impact factor: 16.971

6.  Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes.

Authors:  V Lindgren; K L Luskey; D W Russell; U Francke
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

7.  Linkage analysis of myotonic dystrophy and sequences on chromosome 19 using a cloned complement 3 gene probe.

Authors:  K E Davies; J Jackson; R Williamson; P S Harper; S Ball; M Sarfarazi; L Meredith; G Fey
Journal:  J Med Genet       Date:  1983-08       Impact factor: 6.318

8.  Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia.

Authors:  T L Yang-Feng; U Francke; A Ullrich
Journal:  Science       Date:  1985-05-10       Impact factor: 47.728

9.  Insulin binding to myotonic dystrophy fibroblasts.

Authors:  L Lam; A J Hudson; K P Strickland; G J Tevaarwerk
Journal:  J Neurol Sci       Date:  1983-02       Impact factor: 3.181

10.  The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

Authors:  D J Shaw; A L Meredith; M Sarfarazi; S M Huson; J D Brook; O Myklebost; P S Harper
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132
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  6 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors:  H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

Review 3.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 4.  Mouse chromosome 8.

Authors:  J D Ceci
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 5.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

Review 6.  Molecular analysis of muscular dystrophy.

Authors:  K E Davies; S J Kenwrick; M N Patterson; T J Smith; S M Forrest; H R Dorkins; G S Cross; S B England
Journal:  J Muscle Res Cell Motil       Date:  1988-02       Impact factor: 2.698
  6 in total

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