Literature DB >> 2983222

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.

A Ullrich, J R Bell, E Y Chen, R Herrera, L M Petruzzelli, T J Dull, A Gray, L Coussens, Y C Liao, M Tsubokawa.   

Abstract

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

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Year:  1985        PMID： 2983222     DOI： 10.1038/313756a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  487 in total

1.  Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.

Authors:  T C Elleman; M J Frenkel; P A Hoyne; N M McKern; L Cosgrove; D R Hewish; K M Jachno; J D Bentley; S E Sankovich; C W Ward
Journal:  Biochem J       Date:  2000-05-01       Impact factor: 3.857

Review 2.  Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.

Authors:  A Virkamäki; K Ueki; C R Kahn
Journal:  J Clin Invest       Date:  1999-04       Impact factor: 14.808

Review 3.  Post-transcriptional regulation in metabolic diseases.

Authors:  Wook Kim; Eun Kyung Lee
Journal:  RNA Biol       Date:  2012-06-01       Impact factor: 4.652

Review 4.  The insulin-like growth factor family of ligands, receptors, and binding proteins.

Authors:  R F Krywicki; D Yee
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

Review 5.  Insulin and insulin-like growth factor receptors in the nervous system.

Authors:  M Adamo; M K Raizada; D LeRoith
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

6.  Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.

Authors:  Stéphane Dalle; Takeshi Imamura; David W Rose; Dorothy Sears Worrall; Satoshi Ugi; Christopher J Hupfeld; Jerrold M Olefsky
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

7.  Effect of basic polycations and proteins on purified insulin receptor. Insulin-independent activation of the receptor tyrosine-specific protein kinase by poly(L-lysine).

Authors:  Y Fujita-Yamaguchi; D B Sacks; J M McDonald; D Sahal; S Kathuria
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

8.  Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activity.

Authors:  F Viñals; X Testar; M Palacín; A Zorzano
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

9.  Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes.

Authors:  L Mosthaf; J Eriksson; H U Häring; L Groop; E Widen; A Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

10.  Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.

Authors:  L M Chuang; M G Myers; G A Seidner; M J Birnbaum; M F White; C R Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205
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