Karine Toupin-April1,2, Jennifer Barton3,4, Liana Fraenkel3,4, Linda C Li3,4, Peter Brooks3,4, Maarten De Wit3,4, Dawn Stacey3,4, France Légaré3,4, Alexa Meara3,4, Beverley Shea3,4, Anne Lyddiatt3,4, Cathie Hofstetter3,4, Laure Gossec3,4, Robin Christensen3,4, Marieke Scholte-Voshaar3,4, Maria E Suarez-Almazor3,4, Annelies Boonen3,4, Tanya Meade3,4, Lyn March3,4, Christoph Pohl3,4, Janet Elizabeth Jull3,4, Sigogini Sivarajah3,4, Willemina Campbell3,4, Rieke Alten3,4, Suvi Karuranga3,4, Esi Morgan3,4, Jessica Kaufman3,4, Sophie Hill3,4, Lara J Maxwell3,4, Vivian Welch3,4, Dorcas Beaton3,4, Yasser El-Miedany3,4, Peter S Tugwell3,4. 1. From the Children's Hospital of Eastern Ontario Research Institute, Ottawa; Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa, and Department of Epidemiology and Community Medicine, and Department of Medicine, Faculty of Medicine, University of Ottawa; School of Nursing, University of Ottawa; Integrated Knowledge Translation Network and University of Ottawa; Ottawa Hospital Research Institute, Centre for Practice-Changing Research and University of Ottawa; Bruyère Research Institute, Bruyère Continuing Care and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Epidemiology and Community Medicine, Faculty of Medicine, and Institute of Population Health, Centre for Global Health, University of Ottawa, Ottawa; Musculoskeletal Health and Outcomes Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital; Institute for Work and Health, Institute Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario; Department of Physical Therapy, University of British Columbia; Arthritis Research Centre of Canada, Vancouver, British, Columbia; Department of Family Medicine and Emergency Medicine, Université Laval, Quebec City, Montreal, Canada; VA Portland Health Care System; Oregon Health and Science University, Portland, Oregon; Department of Internal Medicine, Yale University, New Haven, Connecticut; The Ohio State University, Columbus; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; School of Population and Global Health, University of Melbourne; Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne; Western Sydney University and Faculty of Medicine, University of Sydney; Department of Medicine, University of Sydney, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia; VU Medical Centre, Amsterdam; Department Psychology, Health and Technology, University of Twente, Enschede; Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and Caphri Research Institute, Maastricht University, Maastricht; Access to Medicine Foundation, Haarlem, the Netherlands; Sorbonne Universités, UPMC Univ Paris 06, GRC-08; Pitie-Salpétrière Hospital, AP-HP, Rheumatology Department, Paris, France; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Internal Medicine II Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin, Berlin, Germany; Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt; King's College London, London, UK. ktoupin@cheo.on.ca. 2. K. Toupin-April, PhD, Associate Scientist, Children's Hospital of Eastern Ontario Research Institute, and Assistant Professor, Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa; J. Barton, MD, VA Portland Health Care System, and Associate Professor, Oregon Health and Science University; L. Fraenkel, MD, Professor of Medicine, Department of Internal Medicine, Yale University; L.C. Li, PT, PhD, Professor, Department of Physical Therapy, University of British Columbia, and Senior Scientist, Arthritis Research Centre of Canada; P. Brooks, MD, Professor, School of Population and Global Health, University of Melbourne; M. De Wit, PhD, Patient Research Partner, VU Medical Centre; D. Stacey, RN, PhD, Full Professor, School of Nursing, University of Ottawa, and Senior Scientist, The Ottawa Hospital Research Institute; F. Légaré, MD, PhD, Full Professor, Department of Family Medicine and Emergency Medicine, Université Laval; A. Meara, MD, The Ohio State University; B. Shea, PhD, Clinical Scientist, Bruyère Research Institute, and Senior Methodologist, Ottawa Health Research Institute, and Adjunct Professor, Department of Epidemiology and Community Medicine, University of Ottawa; A. Lyddiatt, Patient Research Partner; C. Hofstetter, Patient Research Partner; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, GRC-08, and Pitie-Salpétrière Hospital, AP-HP, Rheumatology Department; R. Christensen, PhD, Professor, Senior Biostatistician, Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; M. Scholte-Voshaar, MSc, Patient Research Partner, Department Psychology, Health and Technology, University of Twente; M.E. Suarez-Almazor MD, PhD, Professor, Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center; A. Boonen, MD, PhD, Professor of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and Caphri Research Institute, Maastricht University; T. Meade, PhD, Professor, Western Sydney University and Faculty of Medicine, University of Sydney; L. March, MD, Professor, Department of Medicine, University of Sydney, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital; C. Pohl, MD, Rheumatologist, Department of Internal Medicine II Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin; J.E. Jull, OT, PhD, Postdoctoral Fellow, Integrated Knowledge Translation Network and University of Ottawa; S. Sivarajah, BSc, Research Assistant, Children's Hospital of Eastern Ontario Research Institute; W. Campbell, LLB, Patient Research Partner; R. Alten, MD, PhD, Professor of Medicine, Head of Department of Internal Medicine II, Director of Rheumatology Research Center, Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin; S. Karuranga, MPH, Researcher, Access to Medicine Foundation; E. Morgan, MD, Associate Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center; J. Kaufman, BSc, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University; S. Hill, PhD, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University; L.J. Maxwell, PhD, Ottawa Hospital Research Institute, Centre for Practice-Changing Research and University of Ottawa; V. Welch, PhD, Scientist, Bruyère Research Institute, Bruyère Continuing Care and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa; D. Beaton, PhD, Musculoskeletal Health and Outcomes Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Senior Scientist, Institute for Work and Health, Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; Y. El-Miedany, MD, Professor, Rheumatology and Rehabilitation, Ain Shams University, and Honorary Senior Clinical Lecturer, King's College London; P.S. Tugwell, MD, Professor, Department of Medicine, Faculty of Medicine, University of Ottawa, and Senior Scientist, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Epidemiology and Community Medicine, Faculty of Medicine, and Institute of Population Health, Centre for Global Health, University of Ottawa. ktoupin@cheo.on.ca. 3. From the Children's Hospital of Eastern Ontario Research Institute, Ottawa; Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa, and Department of Epidemiology and Community Medicine, and Department of Medicine, Faculty of Medicine, University of Ottawa; School of Nursing, University of Ottawa; Integrated Knowledge Translation Network and University of Ottawa; Ottawa Hospital Research Institute, Centre for Practice-Changing Research and University of Ottawa; Bruyère Research Institute, Bruyère Continuing Care and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Epidemiology and Community Medicine, Faculty of Medicine, and Institute of Population Health, Centre for Global Health, University of Ottawa, Ottawa; Musculoskeletal Health and Outcomes Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital; Institute for Work and Health, Institute Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario; Department of Physical Therapy, University of British Columbia; Arthritis Research Centre of Canada, Vancouver, British, Columbia; Department of Family Medicine and Emergency Medicine, Université Laval, Quebec City, Montreal, Canada; VA Portland Health Care System; Oregon Health and Science University, Portland, Oregon; Department of Internal Medicine, Yale University, New Haven, Connecticut; The Ohio State University, Columbus; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; School of Population and Global Health, University of Melbourne; Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne; Western Sydney University and Faculty of Medicine, University of Sydney; Department of Medicine, University of Sydney, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia; VU Medical Centre, Amsterdam; Department Psychology, Health and Technology, University of Twente, Enschede; Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and Caphri Research Institute, Maastricht University, Maastricht; Access to Medicine Foundation, Haarlem, the Netherlands; Sorbonne Universités, UPMC Univ Paris 06, GRC-08; Pitie-Salpétrière Hospital, AP-HP, Rheumatology Department, Paris, France; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Internal Medicine II Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin, Berlin, Germany; Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt; King's College London, London, UK. 4. K. Toupin-April, PhD, Associate Scientist, Children's Hospital of Eastern Ontario Research Institute, and Assistant Professor, Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa; J. Barton, MD, VA Portland Health Care System, and Associate Professor, Oregon Health and Science University; L. Fraenkel, MD, Professor of Medicine, Department of Internal Medicine, Yale University; L.C. Li, PT, PhD, Professor, Department of Physical Therapy, University of British Columbia, and Senior Scientist, Arthritis Research Centre of Canada; P. Brooks, MD, Professor, School of Population and Global Health, University of Melbourne; M. De Wit, PhD, Patient Research Partner, VU Medical Centre; D. Stacey, RN, PhD, Full Professor, School of Nursing, University of Ottawa, and Senior Scientist, The Ottawa Hospital Research Institute; F. Légaré, MD, PhD, Full Professor, Department of Family Medicine and Emergency Medicine, Université Laval; A. Meara, MD, The Ohio State University; B. Shea, PhD, Clinical Scientist, Bruyère Research Institute, and Senior Methodologist, Ottawa Health Research Institute, and Adjunct Professor, Department of Epidemiology and Community Medicine, University of Ottawa; A. Lyddiatt, Patient Research Partner; C. Hofstetter, Patient Research Partner; L. Gossec, MD, PhD, Sorbonne Universités, UPMC Univ Paris 06, GRC-08, and Pitie-Salpétrière Hospital, AP-HP, Rheumatology Department; R. Christensen, PhD, Professor, Senior Biostatistician, Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; M. Scholte-Voshaar, MSc, Patient Research Partner, Department Psychology, Health and Technology, University of Twente; M.E. Suarez-Almazor MD, PhD, Professor, Department of General Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Texas MD Anderson Cancer Center; A. Boonen, MD, PhD, Professor of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center and Caphri Research Institute, Maastricht University; T. Meade, PhD, Professor, Western Sydney University and Faculty of Medicine, University of Sydney; L. March, MD, Professor, Department of Medicine, University of Sydney, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital; C. Pohl, MD, Rheumatologist, Department of Internal Medicine II Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin; J.E. Jull, OT, PhD, Postdoctoral Fellow, Integrated Knowledge Translation Network and University of Ottawa; S. Sivarajah, BSc, Research Assistant, Children's Hospital of Eastern Ontario Research Institute; W. Campbell, LLB, Patient Research Partner; R. Alten, MD, PhD, Professor of Medicine, Head of Department of Internal Medicine II, Director of Rheumatology Research Center, Rheumatology, Clinical Immunology, Osteology, Physical Therapy and Sports Medicine, Schlosspark-Klinik, Charité, University Medicine Berlin; S. Karuranga, MPH, Researcher, Access to Medicine Foundation; E. Morgan, MD, Associate Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center; J. Kaufman, BSc, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University; S. Hill, PhD, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University; L.J. Maxwell, PhD, Ottawa Hospital Research Institute, Centre for Practice-Changing Research and University of Ottawa; V. Welch, PhD, Scientist, Bruyère Research Institute, Bruyère Continuing Care and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa; D. Beaton, PhD, Musculoskeletal Health and Outcomes Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Senior Scientist, Institute for Work and Health, Associate Professor, Institute Health Policy, Management and Evaluation, University of Toronto; Y. El-Miedany, MD, Professor, Rheumatology and Rehabilitation, Ain Shams University, and Honorary Senior Clinical Lecturer, King's College London; P.S. Tugwell, MD, Professor, Department of Medicine, Faculty of Medicine, University of Ottawa, and Senior Scientist, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Epidemiology and Community Medicine, Faculty of Medicine, and Institute of Population Health, Centre for Global Health, University of Ottawa.
Abstract
OBJECTIVE: The aim of this Outcome Measures in Rheumatology (OMERACT) Working Group was to determine the core set of outcome domains and subdomains for measuring the effectiveness of shared decision-making (SDM) interventions in rheumatology clinical trials. METHODS: Following the OMERACT Filter 2.0, and based on a previous literature review of SDM outcome domains and a nominal group process at OMERACT 2014, (1) an online Delphi survey was conducted to gather feedback on the draft core set and refine its domains and subdomains, and (2) a workshop was held at the OMERACT 2016 meeting to gain consensus on the draft core set. RESULTS: A total of 170 participants completed Round 1 of the Delphi survey, and 116 completed Round 2. Respondents came from 29 countries, with 49% being patients/caregivers. Results showed that 14 out of the 17 subdomains within the 7 domains exceeded the 70% criterion (endorsement ranged from 83% to 100% of respondents). At OMERACT 2016, only 8% of the 96 attendees were patients/caregivers. Despite initial votes of support in breakout groups, there was insufficient comfort about the conceptualization of these 7 domains and 17 subdomains for these to be endorsed at OMERACT 2016 (endorsement ranged from 17% to 68% of participants). CONCLUSION: Differences between the Delphi survey and consensus meeting may be explained by the manner in which the outcomes were presented, variations in participant characteristics, and the context of voting. Further efforts are needed to address the limited understanding of SDM and its outcomes among OMERACT participants.
OBJECTIVE: The aim of this Outcome Measures in Rheumatology (OMERACT) Working Group was to determine the core set of outcome domains and subdomains for measuring the effectiveness of shared decision-making (SDM) interventions in rheumatology clinical trials. METHODS: Following the OMERACT Filter 2.0, and based on a previous literature review of SDM outcome domains and a nominal group process at OMERACT 2014, (1) an online Delphi survey was conducted to gather feedback on the draft core set and refine its domains and subdomains, and (2) a workshop was held at the OMERACT 2016 meeting to gain consensus on the draft core set. RESULTS: A total of 170 participants completed Round 1 of the Delphi survey, and 116 completed Round 2. Respondents came from 29 countries, with 49% being patients/caregivers. Results showed that 14 out of the 17 subdomains within the 7 domains exceeded the 70% criterion (endorsement ranged from 83% to 100% of respondents). At OMERACT 2016, only 8% of the 96 attendees were patients/caregivers. Despite initial votes of support in breakout groups, there was insufficient comfort about the conceptualization of these 7 domains and 17 subdomains for these to be endorsed at OMERACT 2016 (endorsement ranged from 17% to 68% of participants). CONCLUSION: Differences between the Delphi survey and consensus meeting may be explained by the manner in which the outcomes were presented, variations in participant characteristics, and the context of voting. Further efforts are needed to address the limited understanding of SDM and its outcomes among OMERACT participants.
Entities:
Keywords:
OMERACT; RHEUMATOLOGY; SHARED DECISION MAKING
Authors: Glyn Elwyn; Annette O'Connor; Dawn Stacey; Robert Volk; Adrian Edwards; Angela Coulter; Richard Thomson; Alexandra Barratt; Michael Barry; Steven Bernstein; Phyllis Butow; Aileen Clarke; Vikki Entwistle; Deb Feldman-Stewart; Margaret Holmes-Rovner; Hilary Llewellyn-Thomas; Nora Moumjid; Al Mulley; Cornelia Ruland; Karen Sepucha; Alan Sykes; Tim Whelan Journal: BMJ Date: 2006-08-14
Authors: Maarten Boers; John R Kirwan; George Wells; Dorcas Beaton; Laure Gossec; Maria-Antonietta d'Agostino; Philip G Conaghan; Clifton O Bingham; Peter Brooks; Robert Landewé; Lyn March; Lee S Simon; Jasvinder A Singh; Vibeke Strand; Peter Tugwell Journal: J Clin Epidemiol Date: 2014-02-28 Impact factor: 6.437
Authors: L Gossec; J S Smolen; S Ramiro; M de Wit; M Cutolo; M Dougados; P Emery; R Landewé; S Oliver; D Aletaha; N Betteridge; J Braun; G Burmester; J D Cañete; N Damjanov; O FitzGerald; E Haglund; P Helliwell; T K Kvien; R Lories; T Luger; M Maccarone; H Marzo-Ortega; D McGonagle; I B McInnes; I Olivieri; K Pavelka; G Schett; J Sieper; F van den Bosch; D J Veale; J Wollenhaupt; A Zink; D van der Heijde Journal: Ann Rheum Dis Date: 2015-12-07 Impact factor: 19.103
Authors: Dawn Stacey; France Légaré; Nananda F Col; Carol L Bennett; Michael J Barry; Karen B Eden; Margaret Holmes-Rovner; Hilary Llewellyn-Thomas; Anne Lyddiatt; Richard Thomson; Lyndal Trevena; Julie H C Wu Journal: Cochrane Database Syst Rev Date: 2014-01-28
Authors: Josef S Smolen; Daniel Aletaha; Johannes W J Bijlsma; Ferdinand C Breedveld; Dimitrios Boumpas; Gerd Burmester; Bernard Combe; Maurizio Cutolo; Maarten de Wit; Maxime Dougados; Paul Emery; Alan Gibofsky; Juan Jesus Gomez-Reino; Boulos Haraoui; Joachim Kalden; Edward C Keystone; Tore K Kvien; Iain McInnes; Emilio Martin-Mola; Carlomaurizio Montecucco; Monika Schoels; Désirée van der Heijde; Desirée van der Heijde Journal: Ann Rheum Dis Date: 2010-03-09 Impact factor: 19.103
Authors: Josef S Smolen; Robert Landewé; Ferdinand C Breedveld; Maya Buch; Gerd Burmester; Maxime Dougados; Paul Emery; Cécile Gaujoux-Viala; Laure Gossec; Jackie Nam; Sofia Ramiro; Kevin Winthrop; Maarten de Wit; Daniel Aletaha; Neil Betteridge; Johannes W J Bijlsma; Maarten Boers; Frank Buttgereit; Bernard Combe; Maurizio Cutolo; Nemanja Damjanov; Johanna M W Hazes; Marios Kouloumas; Tore K Kvien; Xavier Mariette; Karel Pavelka; Piet L C M van Riel; Andrea Rubbert-Roth; Marieke Scholte-Voshaar; David L Scott; Tuulikki Sokka-Isler; John B Wong; Désirée van der Heijde Journal: Ann Rheum Dis Date: 2013-10-25 Impact factor: 19.103
Authors: Karen R Sepucha; Cornelia M Borkhoff; Joanne Lally; Carrie A Levin; Daniel D Matlock; Chirk Jenn Ng; Mary E Ropka; Dawn Stacey; Natalie Joseph-Williams; Celia E Wills; Richard Thomson Journal: BMC Med Inform Decis Mak Date: 2013-11-29 Impact factor: 2.796
Authors: Karine Toupin-April; Jennifer L Barton; Liana Fraenkel; Alexa Meara; Linda C Li; Peter Brooks; Maarten de Wit; Dawn Stacey; France Légaré; Beverley Shea; Anne Lyddiatt; Cathie Hofstetter; Robin Christensen; Marieke Scholte Voshaar; Maria E Suarez-Almazor; Annelies Boonen; Tanya Meade; Lyn March; Janet Elizabeth Jull; Willemina Campbell; Rieke Alten; Suvi Karuranga; Esi M Morgan; Ayano Kelly; Jessica Kaufman; Sophie Hill; Lara J Maxwell; Dorcas Beaton; Yasser El-Miedany; Shikha Mittoo; Susan J Bartlett; Jasvinder A Singh; Peter S Tugwell Journal: J Rheumatol Date: 2019-02-01 Impact factor: 4.666
Authors: R R van Tol; E van Zwietering; J Kleijnen; J Melenhorst; L P S Stassen; C D Dirksen; S O Breukink Journal: Int J Colorectal Dis Date: 2018-04-22 Impact factor: 2.571
Authors: Alberto Floris; Gerard Espinosa; Luisa Serpa Pinto; Nikolaos Kougkas; Andrea Lo Monaco; Giuseppe Lopalco; Ida Orlando; George Bertsias; Luca Cantarini; Ricard Cervera; João Correia; Marcello Govoni; Florenzo Iannone; Alessandro Mathieu; Piergiorgio Neri; Ana Martins Silva; Carlos Vasconcelos; Monica Muntoni; Alberto Cauli; Matteo Piga Journal: Arthritis Res Ther Date: 2020-11-25 Impact factor: 5.156
Authors: Ayano Kelly; Allison Tong; Kathleen Tymms; Lyn March; Jonathan C Craig; Mary De Vera; Vicki Evans; Geraldine Hassett; Karine Toupin-April; Bart van den Bemt; Armando Teixeira-Pinto; Rieke Alten; Susan J Bartlett; Willemina Campbell; Therese Dawson; Michael Gill; Renske Hebing; Alexa Meara; Robby Nieuwlaat; Yomei Shaw; Jasvinder A Singh; Maria Suarez-Almazor; Daniel Sumpton; Peter Wong; Robin Christensen; Dorcas Beaton; Maarten de Wit; Peter Tugwell Journal: Trials Date: 2018-03-27 Impact factor: 2.279