Bhupalam Pradeepkumar1, C P Bhavyamadhuri2, Y Padmanabhareddy3, K V Veerabhadrappa4, Gorantla Narayana5, C Haranath6, K Somasekharreddy7, Akkiraju Sudheer7. 1. Associate Professor and Head, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 2. Pharmacy Student, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 3. Principal, Department of Pharmaceutical Analysis, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 4. Associate Professor, Department of Pharmacognasy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 5. Associate Professor, Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 6. Associate Professor, Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India. 7. Associate Professor, Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapur, Andhra Pradesh, India.
Abstract
INTRODUCTION: Peltophorum pterocarpum is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. Peltophorum pterocarpum consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity. AIM: To evaluate the antiulcer activity of methanolic extract of the leaves of Peltophorum pterocarpum (MEPP) on albino rats. MATERIALS AND METHODS: The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated. RESULTS: Ulcer index was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Total and free acidity was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Histological analysis also supported the gastro protective effect of MEPP treated groups when compared with control groups. CONCLUSION: The study revealed that MEPP exhibited potential antiulcer activity and showed dose dependent antiulcer effect.
INTRODUCTION:Peltophorum pterocarpum is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. Peltophorum pterocarpum consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity. AIM: To evaluate the antiulcer activity of methanolic extract of the leaves of Peltophorum pterocarpum (MEPP) on albino rats. MATERIALS AND METHODS: The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated. RESULTS:Ulcer index was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Total and free acidity was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Histological analysis also supported the gastro protective effect of MEPP treated groups when compared with control groups. CONCLUSION: The study revealed that MEPP exhibited potential antiulcer activity and showed dose dependent antiulcer effect.
Entities:
Keywords:
Indomethacin; Misoprostol; Pylorus ligation; Ulcer index