Saroj Kumar Sahoo1, Himanshu Bhusan Sahoo2, D Priyadarshini3, G Soundarya4, Ch Kishore Kumar5, K Usha Rani3. 1. Assistant Professor, Department of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India . 2. Assistant Professor, Department of Pharmacology, MKCG Medical College & Hospital , Berhampur, Odisha, India . 3. Assistant Professor, Department of Pharmacology, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India . 4. Assistant Professor, Department of Pharmaceutical Analysis, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India . 5. Assistant Professor, Department of Pharmaceutics, Sri Sivani College of Pharmacy , Srikakulam, Andhra Pradesh, India .
Abstract
BACKGROUND: Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred as peptic ulcers. It affects nearly 10% of world population. AIM: To investigate the antiulcer activity of ethanolic extract of Salvadora indica W. leaves (ESIL) on albino rats. MATERIALS AND METHODS: The present study was carried by pylorus ligation, ethanol and cysteamine induced ulcer models in albino rats. The antiulcer activity of ESIL (150, 300 and 600 mg/kg p.o. for 7 days) was compared with standard drugs (Ranitidine). In pyloric ligation induced ulcer model, the studied parameters were gastric volume, pH, total acidity, free acidity, and ulcer index whereas in ethanol and cysteamine induced ulcer model, the ulcer index was determined for severity of ulcers. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity. RESULTS: In pyloric ligation model; the volume of gastric content, total/free acidity and pepsin activity was significantly decreased at p<0.05 and p<0.01 and pH of the gastric juice was significantly increased at p<0.05 and p<0.01 in ESIL treated groups as compared to control group. All the doses of ESIL showed dose dependent antiulcer effect as well as significant (p<0.05 and p<0.01) reduction in the ulcer index as compared to control group in all the experimental models. CONCLUSION: The results of the study indicate that the ESIL have better potential against ulcer which supports the traditional claims in folklore medicine.
BACKGROUND:Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred as peptic ulcers. It affects nearly 10% of world population. AIM: To investigate the antiulcer activity of ethanolic extract of Salvadora indica W. leaves (ESIL) on albino rats. MATERIALS AND METHODS: The present study was carried by pylorus ligation, ethanol and cysteamine induced ulcer models in albino rats. The antiulcer activity of ESIL (150, 300 and 600 mg/kg p.o. for 7 days) was compared with standard drugs (Ranitidine). In pyloric ligation induced ulcer model, the studied parameters were gastric volume, pH, total acidity, free acidity, and ulcer index whereas in ethanol and cysteamine induced ulcer model, the ulcer index was determined for severity of ulcers. The parameters studied were ulcer index, gastric juice volume, pH, free acidity and total acidity. RESULTS: In pyloric ligation model; the volume of gastric content, total/free acidity and pepsin activity was significantly decreased at p<0.05 and p<0.01 and pH of the gastric juice was significantly increased at p<0.05 and p<0.01 in ESIL treated groups as compared to control group. All the doses of ESIL showed dose dependent antiulcer effect as well as significant (p<0.05 and p<0.01) reduction in the ulcer index as compared to control group in all the experimental models. CONCLUSION: The results of the study indicate that the ESIL have better potential against ulcer which supports the traditional claims in folklore medicine.
Entities:
Keywords:
Antiulcer effect; Cysteamine; Ethanol; Pylorus ligation; Ulcer index
Authors: Bhupalam Pradeepkumar; C P Bhavyamadhuri; Y Padmanabhareddy; K V Veerabhadrappa; Gorantla Narayana; C Haranath; K Somasekharreddy; Akkiraju Sudheer Journal: J Clin Diagn Res Date: 2017-06-01
Authors: Luisa Mota da Silva; Priscila de Souza; Soad K Al Jaouni; Steve Harakeh; Shahram Golbabapour; Sérgio Faloni de Andrade Journal: Evid Based Complement Alternat Med Date: 2018-03-15 Impact factor: 2.629