| Literature DB >> 24130029 |
Jie Zhang1, Yuki Nishimoto, Harukuni Tokuda, Nobutaka Suzuki, Ken Yasukawa, Worapong Kitdamrongtham, Hiroyuki Akazawa, Aranya Manosroi, Jiradej Manosroi, Toshihiro Akihisa.
Abstract
The aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against EpsteinBarr virus early antigen (EBV-EA) activation induced with 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and against melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 melanoma cells, as well as potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity. Two phenolic acid derivatives, bergenin (1) and gallic acid (2), were isolated from the ethyl acetate (AcOEt)-soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV-EA activation and against skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis-inhibitory activities in α-MSH-stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical-scavenging activity.Entities:
Keywords: Anti-tumor-promoting activity; Antioxidant activity; Bergenin; Melanogenesis inhibition; Peltophorum pterocarpum; Radical-scavenging activity
Mesh：
Substances：
Year: 2013 PMID： 24130029 DOI： 10.1002/cbdv.201300182
Source DB: PubMed Journal: Chem Biodivers ISSN： 1612-1872 Impact factor: 2.408