| Literature DB >> 28760898 |
Dan Roizman1,2, Celine Vidaillac1, Michael Givskov1,3, Liang Yang4,5.
Abstract
As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/p BAD -yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.Entities:
Keywords: antibiotic resistance; biofilms; cyclic di-GMP; dispersal; synergism
Mesh:
Substances:
Year: 2017 PMID: 28760898 PMCID: PMC5610510 DOI: 10.1128/AAC.01088-17
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191