C Rauschenberg1, J van Os1,2,3, D Cremers4, M Goedhart4,5, J N M Schieveld6, U Reininghaus1,7. 1. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. 2. Psychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK. 3. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Tilburg School of Humanities, Tilburg University, Tilburg, The Netherlands. 5. Mutsaers Foundation and Educational Institute Wijnberg, Venlo, The Netherlands. 6. Department of Psychiatry and Psychology, Division of Child and Adolescent Psychiatry, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands. 7. Health Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.
Abstract
OBJECTIVE: Childhood trauma (CT) is associated with a range of psychopathologies, including psychosis. However, evidence on underlying mechanisms remains limited. The study aimed to investigate whether CT impacts on youth mental health by modifying sensitivity to stress in daily life. METHOD: The experience sampling method (ESM) was used to measure momentary stress, negative affect and psychotic experiences in 99 adolescents and young adults (43 help-seeking service users, 16 siblings and 40 controls). Before ESM assessments, CT and depressive, anxiety and psychotic symptoms were assessed. RESULTS: Stress sensitivity, that is, the association between momentary stress and (i) negative affect and (ii) psychotic experiences, was modified by physical and emotional abuse and, partially, emotional and physical neglect, but not sexual abuse in service users and controls. While there was strong evidence for increased stress sensitivity in service users when high vs. low levels of CT were compared, a pattern of resilience was evident in controls, with attenuated, or no differences in, stress sensitivity in those with high vs. low CT levels. Less consistent findings were observed in siblings. CONCLUSIONS: Stress sensitivity may be an important risk and resilience mechanism through which CT impacts on mental health in youth.
OBJECTIVE: Childhood trauma (CT) is associated with a range of psychopathologies, including psychosis. However, evidence on underlying mechanisms remains limited. The study aimed to investigate whether CT impacts on youth mental health by modifying sensitivity to stress in daily life. METHOD: The experience sampling method (ESM) was used to measure momentary stress, negative affect and psychotic experiences in 99 adolescents and young adults (43 help-seeking service users, 16 siblings and 40 controls). Before ESM assessments, CT and depressive, anxiety and psychotic symptoms were assessed. RESULTS: Stress sensitivity, that is, the association between momentary stress and (i) negative affect and (ii) psychotic experiences, was modified by physical and emotional abuse and, partially, emotional and physical neglect, but not sexual abuse in service users and controls. While there was strong evidence for increased stress sensitivity in service users when high vs. low levels of CT were compared, a pattern of resilience was evident in controls, with attenuated, or no differences in, stress sensitivity in those with high vs. low CT levels. Less consistent findings were observed in siblings. CONCLUSIONS: Stress sensitivity may be an important risk and resilience mechanism through which CT impacts on mental health in youth.
Authors: Mario Maj; Jim van Os; Marc De Hert; Wolfgang Gaebel; Silvana Galderisi; Michael F Green; Sinan Guloksuz; Philip D Harvey; Peter B Jones; Dolores Malaspina; Patrick McGorry; Jouko Miettunen; Robin M Murray; Keith H Nuechterlein; Victor Peralta; Graham Thornicroft; Ruud van Winkel; Joseph Ventura Journal: World Psychiatry Date: 2021-02 Impact factor: 49.548
Authors: Christian Rauschenberg; Julia C C Schulte-Strathaus; Jim van Os; Matthieu Goedhart; Jan N M Schieveld; Ulrich Reininghaus Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2022-04-25 Impact factor: 4.519
Authors: L-K Pries; B Klingenberg; C Menne-Lothmann; J Decoster; R van Winkel; D Collip; P Delespaul; M De Hert; C Derom; E Thiery; N Jacobs; M Wichers; O Cinar; B D Lin; J J Luykx; B P F Rutten; J van Os; S Guloksuz Journal: Acta Psychiatr Scand Date: 2020-02-21 Impact factor: 6.392
Authors: Lin Zhang; Xueyao Ma; Xianglian Yu; Meizhu Ye; Na Li; Shan Lu; Jiayi Wang Journal: Int J Environ Res Public Health Date: 2021-06-24 Impact factor: 3.390
Authors: I Paetzold; I Myin-Germeys; A Schick; B Nelson; E Velthorst; F Schirmbeck; J van Os; C Morgan; J Hartmann; M van der Gaag; L de Haan; L Valmaggia; P McGuire; M Kempton; U Reininghaus Journal: Epidemiol Psychiatr Sci Date: 2021-05-28 Impact factor: 6.892