Literature DB >> 28758405

Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.

Marion Carayol1, Michael F Leitzmann1, Pietro Ferrari1, Raul Zamora-Ros1, David Achaintre1, Magdalena Stepien1, Julie A Schmidt2, Ruth C Travis2, Kim Overvad3, Anne Tjønneland4, Louise Hansen4, Rudolf Kaaks5, Tilman Kühn5, Heiner Boeing6, Ursula Bachlechner6, Antonia Trichopoulou7,8,9, Christina Bamia7,8, Domenico Palli10, Claudia Agnoli11, Rosario Tumino12, Paolo Vineis13,14, Salvatore Panico15, J Ramón Quirós16, Emilio Sánchez-Cantalejo17,18, José María Huerta18,19, Eva Ardanaz18,20,21, Larraitz Arriola18,22, Antonio Agudo23, Jan Nilsson24, Olle Melander24, Bas Bueno-de-Mesquita13,25,26,27, Petra H Peeters13,28, Nick Wareham29, Kay-Tee Khaw30, Mazda Jenab1, Timothy J Key2, Augustin Scalbert1, Sabina Rinaldi1.   

Abstract

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.

Entities:  

Keywords:  blood; body mass index; metabolic profiling; obesity; targeted metabolome

Mesh：

Substances：

Year:  2017        PMID： 28758405      PMCID： PMC6198936          DOI： 10.1021/acs.jproteome.6b01062

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  38 in total

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Journal:  Nat Med       Date:  2002-11-25       Impact factor: 53.440

2.  Body mass index and risk of cardiovascular disease, cancer and all-cause mortality.

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Journal:  Can J Public Health       Date:  2012 Mar-Apr

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Authors:  Panagiotis Kougias; Hong Chai; Peter H Lin; Alan B Lumsden; Qizhi Yao; Changyi Chen
Journal:  Med Sci Monit       Date:  2005-12-19

4.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Authors:  Christopher B Newgard; Jie An; James R Bain; Michael J Muehlbauer; Robert D Stevens; Lillian F Lien; Andrea M Haqq; Svati H Shah; Michelle Arlotto; Cris A Slentz; James Rochon; Dianne Gallup; Olga Ilkayeva; Brett R Wenner; William S Yancy; Howard Eisenson; Gerald Musante; Richard S Surwit; David S Millington; Mark D Butler; Laura P Svetkey
Journal:  Cell Metab       Date:  2009-04       Impact factor: 27.287

5.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection.

Authors:  E Riboli; K J Hunt; N Slimani; P Ferrari; T Norat; M Fahey; U R Charrondière; B Hémon; C Casagrande; J Vignat; K Overvad; A Tjønneland; F Clavel-Chapelon; A Thiébaut; J Wahrendorf; H Boeing; D Trichopoulos; A Trichopoulou; P Vineis; D Palli; H B Bueno-De-Mesquita; P H M Peeters; E Lund; D Engeset; C A González; A Barricarte; G Berglund; G Hallmans; N E Day; T J Key; R Kaaks; R Saracci
Journal:  Public Health Nutr       Date:  2002-12       Impact factor: 4.022

6.  Differences between human plasma and serum metabolite profiles.

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Journal:  PLoS One       Date:  2011-07-08       Impact factor: 3.240

7.  Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort.

Authors:  Julie A Schmidt; Sabina Rinaldi; Pietro Ferrari; Marion Carayol; David Achaintre; Augustin Scalbert; Amanda J Cross; Marc J Gunter; Georgina K Fensom; Paul N Appleby; Timothy J Key; Ruth C Travis
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9.  Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.

Authors:  Peter Würtz; Qin Wang; Antti J Kangas; Rebecca C Richmond; Joni Skarp; Mika Tiainen; Tuulia Tynkkynen; Pasi Soininen; Aki S Havulinna; Marika Kaakinen; Jorma S Viikari; Markku J Savolainen; Mika Kähönen; Terho Lehtimäki; Satu Männistö; Stefan Blankenberg; Tanja Zeller; Jaana Laitinen; Anneli Pouta; Pekka Mäntyselkä; Mauno Vanhala; Paul Elliott; Kirsi H Pietiläinen; Samuli Ripatti; Veikko Salomaa; Olli T Raitakari; Marjo-Riitta Järvelin; George Davey Smith; Mika Ala-Korpela
Journal:  PLoS Med       Date:  2014-12-09       Impact factor: 11.069

10.  Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study.

Authors:  Veronika Fedirko; Talita Duarte-Salles; Christina Bamia; Antonia Trichopoulou; Krasimira Aleksandrova; Dimitrios Trichopoulos; Elisabeth Trepo; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Marina Kvaskoff; Tilman Kühn; Annie Lukanova; Heiner Boeing; Brian Buijsse; Eleni Klinaki; Chrysanthi Tsimakidi; Alessio Naccarati; Giovanna Tagliabue; Salvatore Panico; Rosario Tumino; Domenico Palli; H Bas Bueno-de-Mesquita; Peter D Siersema; Petra H Peters; Eiliv Lund; Magritt Brustad; Karina Standahl Olsen; Elisabete Weiderpass; Raul Zamora-Ros; María-José Sánchez; Eva Ardanaz; Pilar Amiano; Carmen Navarro; J Ramón Quirós; Mårten Werner; Malin Sund; Björn Lindkvist; Johan Malm; Ruth C Travis; Kay-Tee Khaw; Magdalena Stepien; Augustin Scalbert; Isabelle Romieu; Pagona Lagiou; Elio Riboli; Mazda Jenab
Journal:  Hepatology       Date:  2014-08-28       Impact factor: 17.425
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Review 1.  Metabolomics in epidemiologic research: challenges and opportunities for early-career epidemiologists.

Authors:  Eline H van Roekel; Erikka Loftfield; Rachel S Kelly; Oana A Zeleznik; Krista A Zanetti
Journal:  Metabolomics       Date:  2019-01-07       Impact factor: 4.290

2.  Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort.

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3.  Body Composition and Metabolomics in the Alberta Physical Activity and Breast Cancer Prevention Trial.

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5.  Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.

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6.  Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study.

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8.  Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study.

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Review 9.  A Scoping Review: Metabolomics Signatures Associated with Animal and Plant Protein Intake and Their Potential Relation with Cardiometabolic Risk.

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