Literature DB >> 30830482

Metabolomics in epidemiologic research: challenges and opportunities for early-career epidemiologists.

Eline H van Roekel1, Erikka Loftfield2, Rachel S Kelly3, Oana A Zeleznik3, Krista A Zanetti4.   

Abstract

BACKGROUND: The application of metabolomics to epidemiologic studies is increasing. AIM OF REVIEW: Here, we describe the challenges and opportunities facing early-career epidemiologists aiming to apply metabolomics to their research. KEY SCIENTIFIC CONCEPTS OF REVIEW: Many challenges inherent to metabolomics may provide early-career epidemiologists with the opportunity to play a pivotal role in answering critical methodological questions and moving the field forward. Although generating large-scale high-quality metabolomics data can be challenging, data can be accessed through public databases, collaboration with senior researchers or participation within interest groups. Such efforts may also assist with obtaining funding, provide knowledge on training resources, and help early-career epidemiologists to publish in the field of metabolomics.

Entities:  

Keywords:  Challenges; Early-career scientists; Epidemiology; Metabolomics; Opportunities

Mesh:

Year:  2019        PMID: 30830482      PMCID: PMC7844759          DOI: 10.1007/s11306-018-1468-z

Source DB:  PubMed          Journal:  Metabolomics        ISSN: 1573-3882            Impact factor:   4.290


  45 in total

1.  The use of metabolomics in population-based research.

Authors:  L Joseph Su; Oliver Fiehn; Padma Maruvada; Steven C Moore; Stephen J O'Keefe; David S Wishart; Krista A Zanetti
Journal:  Adv Nutr       Date:  2014-11-14       Impact factor: 8.701

2.  Nutritional metabolomics and breast cancer risk in a prospective study.

Authors:  Mary C Playdon; Regina G Ziegler; Joshua N Sampson; Rachael Stolzenberg-Solomon; Henry J Thompson; Melinda L Irwin; Susan T Mayne; Robert N Hoover; Steven C Moore
Journal:  Am J Clin Nutr       Date:  2017-06-28       Impact factor: 7.045

3.  Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer.

Authors:  Kristin A Guertin; Erikka Loftfield; Simina M Boca; Joshua N Sampson; Steven C Moore; Qian Xiao; Wen-Yi Huang; Xiaoqin Xiong; Neal D Freedman; Amanda J Cross; Rashmi Sinha
Journal:  Am J Clin Nutr       Date:  2015-03-11       Impact factor: 7.045

4.  Human metabolic phenotype diversity and its association with diet and blood pressure.

Authors:  Elaine Holmes; Ruey Leng Loo; Jeremiah Stamler; Magda Bictash; Ivan K S Yap; Queenie Chan; Tim Ebbels; Maria De Iorio; Ian J Brown; Kirill A Veselkov; Martha L Daviglus; Hugo Kesteloot; Hirotsugu Ueshima; Liancheng Zhao; Jeremy K Nicholson; Paul Elliott
Journal:  Nature       Date:  2008-04-20       Impact factor: 49.962

5.  Comparison of Collection Methods for Fecal Samples for Discovery Metabolomics in Epidemiologic Studies.

Authors:  Erikka Loftfield; Emily Vogtmann; Joshua N Sampson; Steven C Moore; Heidi Nelson; Rob Knight; Nicholas Chia; Rashmi Sinha
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-08-19       Impact factor: 4.254

6.  Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study.

Authors:  Yan Zheng; Bing Yu; Danny Alexander; Teri A Manolio; David Aguilar; Josef Coresh; Gerardo Heiss; Eric Boerwinkle; Jennifer A Nettleton
Journal:  Am J Epidemiol       Date:  2013-06-20       Impact factor: 4.897

7.  A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study.

Authors:  Nada Assi; Anne Fages; Paolo Vineis; Marc Chadeau-Hyam; Magdalena Stepien; Talita Duarte-Salles; Graham Byrnes; Houda Boumaza; Sven Knüppel; Tilman Kühn; Domenico Palli; Christina Bamia; Hendriek Boshuizen; Catalina Bonet; Kim Overvad; Mattias Johansson; Ruth Travis; Marc J Gunter; Eiliv Lund; Laure Dossus; Bénédicte Elena-Herrmann; Elio Riboli; Mazda Jenab; Vivian Viallon; Pietro Ferrari
Journal:  Mutagenesis       Date:  2015-06-30       Impact factor: 3.000

8.  Human metabolic correlates of body mass index.

Authors:  Steven C Moore; Charles E Matthews; Joshua N Sampson; Rachael Z Stolzenberg-Solomon; Wei Zheng; Qiuyin Cai; Yu Ting Tan; Wong-Ho Chow; Bu-Tian Ji; Da Ke Liu; Qian Xiao; Simina M Boca; Michael F Leitzmann; Gong Yang; Yong Bing Xiang; Rashmi Sinha; Xiao Ou Shu; Amanda J Cross
Journal:  Metabolomics       Date:  2014-04-01       Impact factor: 4.290

Review 9.  Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies.

Authors:  David Broadhurst; Royston Goodacre; Stacey N Reinke; Julia Kuligowski; Ian D Wilson; Matthew R Lewis; Warwick B Dunn
Journal:  Metabolomics       Date:  2018-05-18       Impact factor: 4.290

10.  Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data.

Authors:  Fadhl M Alakwaa; Kumardeep Chaudhary; Lana X Garmire
Journal:  J Proteome Res       Date:  2017-11-27       Impact factor: 4.466

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  9 in total

Review 1.  Building infrastructure at the National Cancer Institute to support metabolomic analyses in epidemiological studies.

Authors:  Krista A Zanetti
Journal:  Metabolomics       Date:  2021-05-03       Impact factor: 4.290

2.  Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes.

Authors:  Ellis Voerman; Vincent W V Jaddoe; Engy Shokry; George J G Ruijter; Janine F Felix; Berthold Koletzko; Romy Gaillard
Journal:  Pediatr Obes       Date:  2021-08-12       Impact factor: 3.910

3.  Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles.

Authors:  Sheetal Hardikar; Richard D Albrechtsen; David Achaintre; Tengda Lin; Svenja Pauleck; Mary Playdon; Andreana N Holowatyj; Biljana Gigic; Petra Schrotz-King; Juergen Boehm; Nina Habermann; Stefanie Brezina; Andrea Gsur; Eline H van Roekel; Matty P Weijenberg; Pekka Keski-Rahkonen; Augustin Scalbert; Jennifer Ose; Cornelia M Ulrich
Journal:  Metabolites       Date:  2020-05-21

4.  Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS).

Authors:  Mary C Playdon; Amit D Joshi; Fred K Tabung; Susan Cheng; Mir Henglin; Andy Kim; Tengda Lin; Eline H van Roekel; Jiaqi Huang; Jan Krumsiek; Ying Wang; Ewy Mathé; Marinella Temprosa; Steven Moore; Bo Chawes; A Heather Eliassen; Andrea Gsur; Marc J Gunter; Sei Harada; Claudia Langenberg; Matej Oresic; Wei Perng; Wei Jie Seow; Oana A Zeleznik
Journal:  Metabolites       Date:  2019-07-17

Review 5.  Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine.

Authors:  Nguyen Phuoc Long; Tran Diem Nghi; Yun Pyo Kang; Nguyen Hoang Anh; Hyung Min Kim; Sang Ki Park; Sung Won Kwon
Journal:  Metabolites       Date:  2020-01-29

6.  Metaboprep: an R package for pre-analysis data description and processing.

Authors:  David A Hughes; Kurt Taylor; Nancy McBride; Matthew A Lee; Dan Mason; Deborah A Lawlor; Nicholas J Timpson; Laura J Corbin
Journal:  Bioinformatics       Date:  2022-02-04       Impact factor: 6.931

Review 7.  Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine.

Authors:  Richard D Beger; Michael A Schmidt; Rima Kaddurah-Daouk
Journal:  Metabolites       Date:  2020-03-27

8.  A population-based resource for intergenerational metabolomics analyses in pregnant women and their children: the Generation R Study.

Authors:  Ellis Voerman; Vincent W V Jaddoe; Olaf Uhl; Engy Shokry; Jeannie Horak; Janine F Felix; Berthold Koletzko; Romy Gaillard
Journal:  Metabolomics       Date:  2020-03-23       Impact factor: 4.290

9.  Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort.

Authors:  Vinicius Verri Hernandes; Nikola Dordevic; Essi Marjatta Hantikainen; Baldur Bragi Sigurdsson; Sigurður Vidir Smárason; Vanessa Garcia-Larsen; Martin Gögele; Giulia Caprioli; Ilaria Bozzolan; Peter P Pramstaller; Johannes Rainer
Journal:  Metabolites       Date:  2022-02-24
  9 in total

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