Galit Levi Dunietz1,2, Claudia Holzman3, Yujia Zhang4, Chenxi Li3, David Todem3, Sheree L Boulet4, Patricia McKane5, Dmitry M Kissin4, Glenn Copeland6, Dana Bernson7, Michael P Diamond8. 1. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. gldt@med.umich.edu. 2. Department of Neurology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5845, USA. gldt@med.umich.edu. 3. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. 4. Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. 5. Maternal and Child Health Epidemiology Section, Michigan Department of Health and Human Services, Lansing, MI, USA. 6. Michigan Department of Health and Human Services, Lansing, MI, USA. 7. Massachusetts Department of Public Health, Boston, MA, USA. 8. Department of Obstetrics and Gynecology, Augusta University, Augusta, GA, USA.
Abstract
PURPOSE: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. METHODS: Population-based assisted reproductive technology surveillance data for 2000-2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. RESULTS: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95% CI 1.0, 1.9) for male infertility to 2.4 (95% CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. CONCLUSIONS: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.
PURPOSE: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. METHODS: Population-based assisted reproductive technology surveillance data for 2000-2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. RESULTS: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95% CI 1.0, 1.9) for male infertility to 2.4 (95% CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. CONCLUSIONS: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.
Authors: Judy E Stern; Barbara Luke; Michael Tobias; Daksha Gopal; Mark D Hornstein; Hafsatou Diop Journal: Fertil Steril Date: 2015-03-23 Impact factor: 7.329
Authors: Galit Levi Dunietz; Claudia Holzman; Patricia McKane; Chenxi Li; Sheree L Boulet; David Todem; Dmitry M Kissin; Glenn Copeland; Dana Bernson; William M Sappenfield; Michael P Diamond Journal: Fertil Steril Date: 2015-02-20 Impact factor: 7.329
Authors: Sara S Malchau; Anne Loft; Elisabeth C Larsen; Anna-Karina Aaris Henningsen; Steen Rasmussen; Anders Nyboe Andersen; Anja Pinborg Journal: Fertil Steril Date: 2013-03-07 Impact factor: 7.329