Literature DB >> 28742999

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer.

Ana P Gomes1, Tanya Schild1, John Blenis2.   

Abstract

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28742999      PMCID： PMC5705022          DOI： 10.1016/j.devcel.2017.07.004

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

Review 2.  Mammalian polyamine metabolism and function.

Authors:  Anthony E Pegg
Journal:  IUBMB Life       Date:  2009-09       Impact factor: 3.885

3.  mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Authors:  Ning Dai; Joseph Rapley; Matthew Angel; M Fatih Yanik; Michael D Blower; Joseph Avruch
Journal:  Genes Dev       Date:  2011-05-16       Impact factor: 11.361

4.  Spermidine induces autophagy by inhibiting the acetyltransferase EP300.

Authors:  F Pietrocola; S Lachkar; D P Enot; M Niso-Santano; J M Bravo-San Pedro; V Sica; V Izzo; M C Maiuri; F Madeo; G Mariño; G Kroemer
Journal:  Cell Death Differ       Date:  2014-12-19       Impact factor: 15.828

Review 5.  Polyamines and cancer: old molecules, new understanding.

Authors:  Eugene W Gerner; Frank L Meyskens
Journal:  Nat Rev Cancer       Date:  2004-10       Impact factor: 60.716

Review 6.  Targeting polyamine metabolism for cancer therapy and prevention.

Authors:  Tracy R Murray-Stewart; Patrick M Woster; Robert A Casero
Journal:  Biochem J       Date:  2016-10-01       Impact factor: 3.857

Review 7.  Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

Authors:  Robert A Casero; Laurence J Marton
Journal:  Nat Rev Drug Discov       Date:  2007-05       Impact factor: 84.694

8.  Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

Authors:  Ziv Zwighaft; Rona Aviram; Moran Shalev; Liat Rousso-Noori; Judith Kraut-Cohen; Marina Golik; Alexander Brandis; Hans Reinke; Asaph Aharoni; Chaim Kahana; Gad Asher
Journal:  Cell Metab       Date:  2015-10-08       Impact factor: 27.287

Review 9.  Polyamines in aging and disease.

Authors:  Nadège Minois; Didac Carmona-Gutierrez; Frank Madeo
Journal:  Aging (Albany NY)       Date:  2011-08       Impact factor: 5.682

10.  mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Authors:  Amaia Zabala-Letona; Amaia Arruabarrena-Aristorena; Natalia Martín-Martín; Sonia Fernandez-Ruiz; James D Sutherland; Michelle Clasquin; Julen Tomas-Cortazar; Jose Jimenez; Ines Torres; Phong Quang; Pilar Ximenez-Embun; Ruzica Bago; Aitziber Ugalde-Olano; Ana Loizaga-Iriarte; Isabel Lacasa-Viscasillas; Miguel Unda; Verónica Torrano; Diana Cabrera; Sebastiaan M van Liempd; Ylenia Cendon; Elena Castro; Stuart Murray; Ajinkya Revandkar; Andrea Alimonti; Yinan Zhang; Amelia Barnett; Gina Lein; David Pirman; Ana R Cortazar; Leire Arreal; Ludmila Prudkin; Ianire Astobiza; Lorea Valcarcel-Jimenez; Patricia Zuñiga-García; Itziar Fernandez-Dominguez; Marco Piva; Alfredo Caro-Maldonado; Pilar Sánchez-Mosquera; Mireia Castillo-Martín; Violeta Serra; Naiara Beraza; Antonio Gentilella; George Thomas; Mikel Azkargorta; Felix Elortza; Rosa Farràs; David Olmos; Alejo Efeyan; Juan Anguita; Javier Muñoz; Juan M Falcón-Pérez; Rosa Barrio; Teresa Macarulla; Jose M Mato; Maria L Martinez-Chantar; Carlos Cordon-Cardo; Ana M Aransay; Kevin Marks; José Baselga; Josep Tabernero; Paolo Nuciforo; Brendan D Manning; Katya Marjon; Arkaitz Carracedo
Journal:  Nature       Date:  2017-06-28       Impact factor: 49.962
  10 in total
  4 in total

Review 1.  Polyamine metabolism and cancer: treatments, challenges and opportunities.

Authors:  Robert A Casero; Tracy Murray Stewart; Anthony E Pegg
Journal:  Nat Rev Cancer       Date:  2018-11       Impact factor: 60.716

2.  Muscle transcriptome analysis identifies genes involved in ciliogenesis and the molecular cascade associated with intramuscular fat content in Large White heavy pigs.

Authors:  Martina Zappaterra; Silvia Gioiosa; Giovanni Chillemi; Paolo Zambonelli; Roberta Davoli
Journal:  PLoS One       Date:  2020-05-19       Impact factor: 3.240

3.  Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration.

Authors:  Courtney Zasha Rumala; Juan Liu; Jason Wei Locasale; Barbara Ellen Corkey; Jude Thaddeus Deeney; Lucia Egydio Rameh
Journal:  iScience       Date:  2020-01-22

4.  Characterization of nanoparticles combining polyamine detection with photodynamic therapy.

Authors:  Wenting Li; Lingyun Wang; Tianlei Sun; Hao Tang; Brian Bui; Derong Cao; Ruibing Wang; Wei Chen
Journal:  Commun Biol       Date:  2021-07-01
  4 in total

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