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Literature DB >> 17464296

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

Abstract

The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2007 PMID： 17464296 DOI： 10.1038/nrd2243

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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Cited

269 in total

1. Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.

Authors: Elizabeth L Barry; Leila A Mott; Robert S Sandler; Dennis J Ahnen; John A Baron
Journal: Cancer Prev Res (Phila) Date: 2011-09-19

2. Phase I/II clinical trial of 2-difluoromethyl-ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma.

Authors: K A Skorupski; T G O'Brien; T Guerrero; C O Rodriguez; M R Burns
Journal: Vet Comp Oncol Date: 2011-03-08 Impact factor: 2.613

3. A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.

Authors: Andrew J Paris; Zohar Snapir; Cindy D Christopherson; Shirley Y Kwok; Ursula E Lee; Zahra Ghiassi-Nejad; Peri Kocabayoglu; John J Sninsky; Josep M Llovet; Chaim Kahana; Scott L Friedman
Journal: Hepatology Date: 2011-12 Impact factor: 17.425

4. Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

Authors: Kamyar Zahedi; Sharon L Barone; Jie Xu; Nora Steinbergs; Rebecca Schuster; Alex B Lentsch; Hassane Amlal; Jiang Wang; Robert A Casero; Manoocher Soleimani
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-06-21 Impact factor: 4.052

5. Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.

Authors: Mariya S Adachi; Alexander B Taylor; P John Hart; Paul F Fitzpatrick
Journal: Biochemistry Date: 2012-10-15 Impact factor: 3.162

10. Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis.

Authors: Peng-Yuan Wang; Jaladanki N Rao; Tongtong Zou; Lan Liu; Lan Xiao; Ting-Xi Yu; Douglas J Turner; Myriam Gorospe; Jian-Ying Wang
Journal: Biochem J Date: 2010-02-24 Impact factor: 3.857

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

1. Variants downstream of the ornithine decarboxylase gene influence risk of colorectal adenoma and aspirin chemoprevention.

2. Phase I/II clinical trial of 2-difluoromethyl-ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma.

3. A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.

4. Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.

5. Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.

6. Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function.

7. A Landscape of Metabolic Variation across Tumor Types.

8. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.

9. Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation.

10. Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis.