| Literature DB >> 28737393 |
Jonghoon Kim1,2, Hye Rim Cho1,3, Hyejin Jeon1,3, Dokyoon Kim1,2, Changyeong Song1,2, Nohyun Lee4, Seung Hong Choi1,3, Taeghwan Hyeon1,2.
Abstract
Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy.Entities:
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Year: 2017 PMID： 28737393 DOI： 10.1021/jacs.7b05559
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419