Ludivine Larue1, Bauyrzhan Myrzakhmetov2, Amina Ben-Mihoub3, Albert Moussaron4, Noémie Thomas5, Philippe Arnoux6, Francis Baros7, Régis Vanderesse8, Samir Acherar9, Céline Frochot10. 1. Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS, Université de Lorraine, 54000 Nancy, France. ludivine.larue@univ-lorraine.fr. 2. M.Kh. Dulaty Taraz State University, 080012 Taraz, Kazakhstan. baur_86_86@mail.ru. 3. Laboratoire de Chimie Physique Macromoléculaire (LCPM), UMR 7375, CNRS, Université de Lorraine, 54000 Nancy, France. amina.ben-mihoub@univ-lorraine.fr. 4. Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS, Université de Lorraine, 54000 Nancy, France. albert.moussaron@univ-lorraine.fr. 5. Biologie, Signaux et Systèmes en Cancérologie et Neurosciences, CRAN, UMR 7039, Université de Lorraine, CNRS, 54000 Nancy, France. noemie.thomas@univ-lorraine.fr. 6. Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS, Université de Lorraine, 54000 Nancy, France. philippe.arnoux@univ-lorraine.fr. 7. Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS, Université de Lorraine, 54000 Nancy, France. francis.baros@univ-lorraine.fr. 8. Laboratoire de Chimie Physique Macromoléculaire (LCPM), UMR 7375, CNRS, Université de Lorraine, 54000 Nancy, France. regis.vanderesse@univ-lorraine.fr. 9. Laboratoire de Chimie Physique Macromoléculaire (LCPM), UMR 7375, CNRS, Université de Lorraine, 54000 Nancy, France. samir.acherar@univ-lorraine.fr. 10. Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS, Université de Lorraine, 54000 Nancy, France. celine.frochot@univ-lorraine.fr.
Abstract
Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: 1) The use of O2 vehicle; 2) the modification of the tumour microenvironment (TME); 3) combining other therapies with PDT; 4) hypoxia-independent PDT; 5) hypoxia-dependent PDT and 6) fractional PDT.
Photodynamic thepanclass="Disease">rapy (class="Chemical">pan class="Chemical">PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: 1) The use of O2 vehicle; 2) the modification of the tumour microenvironment (TME); 3) combining other therapies with PDT; 4) hypoxia-independent PDT; 5) hypoxia-dependent PDT and 6) fractional PDT.
Authors: Huiying Ding; Haijun Yu; Ying Dong; Ruhai Tian; Gang Huang; David A Boothman; Baran D Sumer; Jinming Gao Journal: J Control Release Date: 2011-08-23 Impact factor: 9.776
Authors: Conor L Evans; Adnan O Abu-Yousif; Yong Jin Park; Oliver J Klein; Jonathan P Celli; Imran Rizvi; Xiang Zheng; Tayyaba Hasan Journal: PLoS One Date: 2011-08-18 Impact factor: 3.240