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Literature DB >> 2873724

Effects of somatostatin on ethanol-induced gastric erosions in the rat: role of mast cells.

Abstract

Somatostatin (S) inhibits hemorrhagic gastric erosions produced by ethanol. In this study we compared the dose-dependent effects of linear (reduced) and cyclic (oxidized) S with respect to mast cell degranulation. The gastric mucosal injuries were more inhibited by linear S than by cyclic S. But linear S aggravated injury at a certain dose (10(-7) mol/rat). Mucosal mast cell degranulation correlated significantly with the area of hemorrhagic mucosal lesions (r = 0.91). Both cytoprotection as well as aggravation potency of S may be connected to gastric mucosal mast cell activity in the rat.

Entities: Chemical Disease Species

Mesh：

Substances：
Ethanol
Somatostatin

Year: 1986 PMID： 2873724 DOI： 10.1007/bf01988040

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

10 in total

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Authors: L Enerbäck
Journal: Acta Pathol Microbiol Scand Date: 1966

2. Mast cells in rat gastrointestinal mucosa. 2. Dye-binding and metachromatic properties.

Authors: L Enerbäck
Journal: Acta Pathol Microbiol Scand Date: 1966

3. Cytoprotection - organoprotection by somatostatin: gastric and hepatic lesions.

Authors: S Szabo; K H Usadel
Journal: Experientia Date: 1982-02-15

4. Somatostatin and cimetidine in peptic-ulcer haemorrhage. A randomised controlled trial.

Authors: L Kayasseh; K Gyr; U Keller; G A Stalder; M Wall
Journal: Lancet Date: 1980-04-19 Impact factor: 79.321

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Authors: D E Hernandez; J W Adcock; C B Nemeroff; A J Prange
Journal: J Neurosci Res Date: 1984 Impact factor: 4.164

6. Histamine release from isolated rat mast cells by neurotensin and other peptides.

Authors: A Sydbom
Journal: Agents Actions Date: 1982-04

7. Gastrointestinal mast cells in health and disease. Part I.

Authors: R F Lemanske; F M Atkins; D D Metcalfe
Journal: J Pediatr Date: 1983-08 Impact factor: 4.406

8. Differences in requirements and actions of various histamine-releasing agents.

Authors: J H Baxter; R Adamik
Journal: Biochem Pharmacol Date: 1978-02-15 Impact factor: 5.858

9. Sulfhydryl compounds may mediate gastric cytoprotection.

Authors: S Szabo; J S Trier; P W Frankel
Journal: Science Date: 1981-10-09 Impact factor: 47.728

10. Dose-dependent effects of linear and cyclic somatostatin on ethanol-induced gastric erosions: the role of mast cells and increased vascular permeability in the rat.

Authors: F Diel; S Szabo
Journal: Regul Pept Date: 1986-02