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Literature DB >> 6120852

Cytoprotection - organoprotection by somatostatin: gastric and hepatic lesions.

Abstract

In rats, the hemorrhagic gastric erosions produced by ethanol, and the fatal hemorrhagic hepatic necrosis induced by phalloidin, were significantly reduced by regular somatostatin, but not by derivatives devoid of -SH containing cysteines. These effects of the hormone were abolished in animals which received, in addition, the sulfhydryl blocker n-ethylmaleimide before the toxic chemicals. Thus, somatostatin exhibits organoprotection dependent on endogenous sulfhydryls.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 6120852 DOI： 10.1007/bf01945097

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

16 in total

Review 1. Pathogenesis of experimental gastric-mucosal injury.

Authors: E Kivilaakso; W Silen
Journal: N Engl J Med Date: 1979-08-16 Impact factor: 91.245

2. Cytoprotection by prostaglandins.

Authors: A Robert
Journal: Gastroenterology Date: 1979-10 Impact factor: 22.682

Review 3. Gastrointestinal cytoprotection by prostaglandins.

Authors: T A Miller; E D Jacobson
Journal: Gut Date: 1979-01 Impact factor: 23.059

4. Protection of gastric mucosa by prostaglandins.

Authors: M I Grossman
Journal: Gastroenterology Date: 1979-09 Impact factor: 22.682

5. Effects of somatostatin on the exocrine pancreas and the release of duodenal hormones.

Authors: S Raptis; W Schlegel; E Lehmann; H C Dollinger; C Zoupas
Journal: Metabolism Date: 1978-09 Impact factor: 8.694

6. Prevention of chemically induced adrenal hemorrhage and lung injury by somatostatin in the rat.

Authors: U Schwedes; S Szabo; K H Usadel
Journal: Metabolism Date: 1978-09 Impact factor: 8.694

7. Extended somatostatin treatment of a patient with bleeding ulcer.

Authors: P Mattes; S Raptis; T Heil; H Rasche; R Scheck
Journal: Horm Metab Res Date: 1975-11 Impact factor: 2.936

8. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.

Authors: A Robert; J E Nezamis; C Lancaster; A J Hanchar
Journal: Gastroenterology Date: 1979-09 Impact factor: 22.682

9. Somatostatin in rat tissues is depleted by cysteamine administration.

Authors: S Szabo; S Reichlin
Journal: Endocrinology Date: 1981-12 Impact factor: 4.736

10. Gastrin and somatostatin secretion by perfused rat stomach: functional linkage of antral peptides.

Authors: B Saffouri; G C Weir; K N Bitar; G M Makhlouf
Journal: Am J Physiol Date: 1980-06

19 in total

Review 1. Non-steroidal anti-inflammatory drug-induced gastropathy. Mechanisms and management.

Authors: S Szabo; W F Spill; K D Rainsford
Journal: Med Toxicol Adverse Drug Exp Date: 1989 Mar-Apr

2. The pharmacological properties of the novel peptide BPC 157 (PL-10).

Authors: P Sikiric
Journal: Inflammopharmacology Date: 1999 Impact factor: 4.473

3. Octreotide treatment in patients with necrotizing pancreatitis and pulmonary failure.

Authors: F Fiedler; G Jauernig; V Keim; A Richter; H J Bender
Journal: Intensive Care Med Date: 1996-09 Impact factor: 17.440

4. Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.

Authors: P Sikirić; S Seiwerth; Z Grabarević; R Rucman; M Petek; V Jagić; B Turković; I Rotkvić; S Mise; I Zoricić; L Jurina; P Konjevoda; M Hanzevacki; D Ljubanović; J Separović; M Gjurasin; M Bratulić; B Artuković; N Jelovac; G Buljat
Journal: Dig Dis Sci Date: 1996-07 Impact factor: 3.199

5. Somatostatin stimulates prostaglandin production by rat gastric epithelial cells in vitro, but is not cytoprotective.

Authors: M Romano; M Razandi; K J Ivey
Journal: Dig Dis Sci Date: 1988-11 Impact factor: 3.199

6. Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress.

Authors: P Sikirić; B Mazul; S Seiwerth; Z Grabarević; R Rucman; M Petek; V Jagić; B Turković; I Rotkvić; S Mise; I Zoricić; L Jurina; P Konjevoda; M Hanzevacki; M Gjurasin; J Separović; D Ljubanović; B Artuković; M Bratulić; M Tisljar; P Miklić; J Sumajstorcić
Journal: Dig Dis Sci Date: 1997-03 Impact factor: 3.199

7. Somatostatin and ranitidine in the control of iatrogenic haemorrhage of the upper gastrointestinal tract.

Authors: F Coraggio; P Scarpato; M Spina; S Lombardi
Journal: Br Med J (Clin Res Ed) Date: 1984-07-28

Review 8. Gastric cytoprotection: a critical appraisal of the concept, methodology, implications, mechanisms and future research prospects.

Authors: N S Parmar; M Tariq; A M Ageel
Journal: Agents Actions Date: 1987-10

9. Effects of long-acting somatostatin analog (SMS 201-995) on eicosanoid synthesis and survival in rats with acute necrotizing pancreatitis.

Authors: B van Ooijen; C J Tinga; W J Kort; F J Zijlstra; S W Lamberts; J H Wilson
Journal: Dig Dis Sci Date: 1992-09 Impact factor: 3.199

10. Acute pancreatitis, bacterial translocation, and different octreotide regimens: an experimental study.

Authors: Osman Güler; Saadet Akturan; Erol Kisli; Iştar Dolapçi; Muzaffer Caydere; Atilla Akova
Journal: Surg Today Date: 2009-09-27 Impact factor: 2.549