Literature DB >> 7280691

Sulfhydryl compounds may mediate gastric cytoprotection.

S Szabo, J S Trier, P W Frankel.   

Abstract

Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.

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Year:  1981        PMID： 7280691     DOI： 10.1126/science.7280691

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  91 in total

1.  Sulfhydryls protect patients against complications of erosive gastritis.

Authors:  A S Salim
Journal:  Dig Dis Sci       Date:  1990-11       Impact factor: 3.199

2.  Putative mechanisms of cytoprotective effect of certain antacids and sucralfate.

Authors:  H Vergin; C Kori-Lindner
Journal:  Dig Dis Sci       Date:  1990-11       Impact factor: 3.199

3.  Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.

Authors:  Irisdalva S Oliveira; Francilene V da Silva; Ana Flávia S C Viana; Márcio R V dos Santos; Lucindo J Quintans-Júnior; Maria do Carmo C Martins; Paulo H M Nunes; Francisco de A Oliveira; Rita de C M Oliveira
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-06-28       Impact factor: 3.000

Review 4.  Non-steroidal anti-inflammatory drug-induced gastropathy. Mechanisms and management.

Authors:  S Szabo; W F Spill; K D Rainsford
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Mar-Apr

Review 5.  Mechanistic aspects of gastric cytoprotection--a review.

Authors:  A Terano
Journal:  Gastroenterol Jpn       Date:  1992-04

6.  Dual effects of N-ethylmaleimide on ethanol-induced gastric lesions in rats.

Authors:  K Takeuchi; M Okada; H Niida; S Okabe
Journal:  Dig Dis Sci       Date:  1991-07       Impact factor: 3.199

7.  Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers.

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Journal:  Dig Dis Sci       Date:  1996-06       Impact factor: 3.199

8.  Analysis of Raw Biofluids by Mass Spectrometry Using Microfluidic Diffusion-Based Separation.

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9.  Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide.

Authors:  I Szelenyi; K Brune
Journal:  Dig Dis Sci       Date:  1986-11       Impact factor: 3.199

10.  Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism.

Authors:  Silvéria Regina de S Lira; Vietla Satyanarayana Rao; Ana Carla S Carvalho; Marjorie M Guedes; Talita C de Morais; Antonia L de Souza; Maria Teresa S Trevisan; Alana F Lima; Mariana H Chaves; Flávia A Santos
Journal:  Inflammopharmacology       Date:  2009-07-16       Impact factor: 4.473
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