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Literature DB >> 2873723

Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?

Abstract

The role of prostaglandins in somatostatin mediated gastric inhibitory effects has been investigated in conscious cats. The effect of somatostatin on pentagastrin-, insulin- and histamine plus bethanechol-stimulated gastric acid and pepsin secretion was determined with and without indomethacin pretreatment. Somatostatin significantly inhibited acid and pepsin secretion and this effect was not diminished by cyclo-oxygenase inhibition. It is concluded that there is no evidence that endogenous prostaglandins mediate the inhibitory effects of somatostatin on gastric acid and pepsin secretion in the cat.

Entities: Chemical Gene Species

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Year: 1986 PMID： 2873723 DOI： 10.1007/bf01988022

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

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References

10 in total

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Authors: R Baker; B M Jaffe; J D Reed; B Shaw; C W Venables
Journal: J Physiol Date: 1978-05 Impact factor: 5.182

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Authors: W Creutzfeldt; R Arnold
Journal: Metabolism Date: 1978-09 Impact factor: 8.694

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Authors: M Albinus; J D Reed; A Gomez-Pan; A V Schally; D H Coy
Journal: Agents Actions Date: 1977-12

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Authors: M Ligumsky; Y Goto; H Debas; T Yamada
Journal: Science Date: 1983-01-21 Impact factor: 47.728

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Authors: C Scarpignato; G Spina; G C Signorini; G Bertaccini
Journal: Res Commun Chem Pathol Pharmacol Date: 1983-02

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Authors: B J Whittle
Journal: Prostaglandins Date: 1981

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Authors: A H Soll
Journal: J Clin Invest Date: 1980-05 Impact factor: 14.808