Literature DB >> 6129701

Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat.

M Ligumsky, Y Goto, H Debas, T Yamada.   

Abstract

Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.

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Year:  1983        PMID： 6129701     DOI： 10.1126/science.6129701

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Somatostatin stimulates prostaglandin production by rat gastric epithelial cells in vitro, but is not cytoprotective.

Authors:  M Romano; M Razandi; K J Ivey
Journal:  Dig Dis Sci       Date:  1988-11       Impact factor: 3.199

2.  Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH.

Authors:  Heidi K Baumgartner; Uzay Kirbiyik; Tamer Coskun; Shaoyou Chu; Marshall H Montrose
Journal:  J Physiol       Date:  2002-11-01       Impact factor: 5.182

3.  Excitation of neurons in the canine area postrema by prostaglandins.

Authors:  D B Briggs; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1986-12       Impact factor: 5.046

4.  Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?

Authors:  M Albinus; G Frisch
Journal:  Agents Actions       Date:  1986-04

5.  Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.

Authors:  Ibrahim A Al Mofleh; Abdulqader A Alhaider; Jaber S Mossa; Mohammed O Al-Soohaibani; Syed Rafatullah
Journal:  World J Gastroenterol       Date:  2007-02-21       Impact factor: 5.742

6.  Attenuation of stress-induced gastric lesions by lansoprazole, PD-136450 and ranitidine in rats.

Authors:  S I Chandranath; S M A Bastaki; A D'Souza; A Adem; J Singh
Journal:  Mol Cell Biochem       Date:  2010-11-30       Impact factor: 3.396

7.  Somatostatin inhibits gastric acid secretion after gastric mucosal prostaglandin synthesis inhibition by indomethacin in man.

Authors:  M H Mogard; V Maxwell; T Kovacs; G Van Deventer; J D Elashoff; T Yamada; G L Kauffman; J H Walsh
Journal:  Gut       Date:  1985-11       Impact factor: 23.059

8.  Prostaglandin release and nociceptor stimulation by peptides.

Authors:  H Juan; W Sametz; S Petronijevic; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-05       Impact factor: 3.000

9.  Role of circulating somatostatin in regulation of gastric acid secretion, gastrin release, and islet cell function. Studies in healthy subjects and duodenal ulcer patients.

Authors:  T J Colturi; R H Unger; M Feldman
Journal:  J Clin Invest       Date:  1984-08       Impact factor: 14.808

10.  Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?

Authors:  S F Aliño
Journal:  Experientia       Date:  1984-09-15
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