Silvio Zaina1, Gertrud Lund2. 1. Department of Medical Sciences, Division of Health Sciences, León Campus, University of Guanajuato, 20 de Enero no. 929, Col. Obregón, 37320, León, GTO, Mexico. szaina@ugto.mx. 2. Department of Genetic Engineering, CINVESTAV Irapuato Unit, Km. 9.6 Libramiento Norte Carretera Irapuato-León, 36821, Irapuato, GTO, Mexico. gertrud.lund@cinvestav.mx.
Abstract
PURPOSE OF REVIEW: The quest for factors and mechanisms responsible for aberrant DNA methylation in human disease-including atherosclerosis-is a promising area of research. This review focuses on the role of fatty acids (FAs) as modulators of DNA methylation-in particular the role of mitochondrial beta-oxidation in FA-induced changes in DNA methylation during the progression of atherosclerosis. RECENT FINDINGS: Recent publications have advanced the knowledge in all areas touched by this review: the causal role of lipids in shaping the DNA methylome, the associations between chronic degenerative disease and mitochondrial function, the lipid composition of the atheroma, and the relevance of DNA hypermethylation in atherosclerosis. Evidence is beginning to emerge, linking the dynamics of FA type abundance, mitochondrial function, and DNA methylation in the atheroma and systemically. In particular, this review highlights mitochondrial beta-oxidation as an important regulator of DNA methylation in metabolic disease. Despite the many questions still unanswered, this area of research promises to identify mechanisms and molecular factors that establish a pathological gene expression pattern in atherosclerosis.
PURPOSE OF REVIEW: The quest for factors and mechanisms responsible for aberrant DNA methylation in human disease-including atherosclerosis-is a promising area of research. This review focuses on the role of fatty acids (FAs) as modulators of DNA methylation-in particular the role of mitochondrial beta-oxidation in FA-induced changes in DNA methylation during the progression of atherosclerosis. RECENT FINDINGS: Recent publications have advanced the knowledge in all areas touched by this review: the causal role of lipids in shaping the DNA methylome, the associations between chronic degenerative disease and mitochondrial function, the lipid composition of the atheroma, and the relevance of DNA hypermethylation in atherosclerosis. Evidence is beginning to emerge, linking the dynamics of FA type abundance, mitochondrial function, and DNA methylation in the atheroma and systemically. In particular, this review highlights mitochondrial beta-oxidation as an important regulator of DNA methylation in metabolic disease. Despite the many questions still unanswered, this area of research promises to identify mechanisms and molecular factors that establish a pathological gene expression pattern in atherosclerosis.
Authors: Stella Aslibekyan; Howard W Wiener; Peter J Havel; Kimber L Stanhope; Diane M O'Brien; Scarlett E Hopkins; Devin M Absher; Hemant K Tiwari; Bert B Boyer Journal: J Nutr Date: 2014-01-29 Impact factor: 4.798
Authors: Kasper Daniel Hansen; Winston Timp; Héctor Corrada Bravo; Sarven Sabunciyan; Benjamin Langmead; Oliver G McDonald; Bo Wen; Hao Wu; Yun Liu; Dinh Diep; Eirikur Briem; Kun Zhang; Rafael A Irizarry; Andrew P Feinberg Journal: Nat Genet Date: 2011-06-26 Impact factor: 38.330
Authors: Jordana T Bell; Pei-Chien Tsai; Tsun-Po Yang; Ruth Pidsley; James Nisbet; Daniel Glass; Massimo Mangino; Guangju Zhai; Feng Zhang; Ana Valdes; So-Youn Shin; Emma L Dempster; Robin M Murray; Elin Grundberg; Asa K Hedman; Alexandra Nica; Kerrin S Small; Emmanouil T Dermitzakis; Mark I McCarthy; Jonathan Mill; Tim D Spector; Panos Deloukas Journal: PLoS Genet Date: 2012-04-19 Impact factor: 5.917
Authors: Lazar A Bojic; David G McLaren; Vinit Shah; Stephen F Previs; Douglas G Johns; Jose M Castro-Perez Journal: Int J Mol Sci Date: 2014-12-15 Impact factor: 5.923
Authors: Elizabeth H Marchlewicz; Dana C Dolinoy; Lu Tang; Samantha Milewski; Tamara R Jones; Jaclyn M Goodrich; Tanu Soni; Steven E Domino; Peter X K Song; Charles F Burant; Vasantha Padmanabhan Journal: Sci Rep Date: 2016-10-07 Impact factor: 4.379
Authors: Natalia G Menzyanova; Svetlana А Pyatina; Elena D Nikolaeva; Alexander V Shabanov; Ivan V Nemtsev; Dmitry P Stolyarov; Dmitry B Dryganov; Eugene V Sakhnov; Ekaterina I Shishatskaya Journal: Toxicol Rep Date: 2018-11-16