Literature DB >> 28732196

Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells.

Kai Fu1, Fengyi Wan2.   

Abstract

In this issue of Cell Chemical Biology,Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28732196      PMCID： PMC5909376          DOI： 10.1016/j.chembiol.2017.07.003

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  10 in total

Review 1.  Wnt/β-catenin signaling and disease.

Authors:  Hans Clevers; Roel Nusse
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

Review 2.  Targeting Wnt signaling: can we safely eradicate cancer stem cells?

Authors:  Fumi Takahashi-Yanaga; Michael Kahn
Journal:  Clin Cancer Res       Date:  2010-06-08       Impact factor: 12.531

Review 3.  NF-κB signaling in cancer stem cells: a promising therapeutic target?

Authors:  K Vazquez-Santillan; J Melendez-Zajgla; L Jimenez-Hernandez; G Martínez-Ruiz; V Maldonado
Journal:  Cell Oncol (Dordr)       Date:  2015-08-29       Impact factor: 6.730

Review 4.  Can we safely target the WNT pathway?

Authors:  Michael Kahn
Journal:  Nat Rev Drug Discov       Date:  2014-07       Impact factor: 84.694

5.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

Authors:  D Bonnet; J E Dick
Journal:  Nat Med       Date:  1997-07       Impact factor: 53.440

6.  Sam68 Allows Selective Targeting of Human Cancer Stem Cells.

Authors:  Yannick D Benoit; Ryan R Mitchell; Ruth M Risueño; Luca Orlando; Borko Tanasijevic; Allison L Boyd; Lili Aslostovar; Kyle R Salci; Zoya Shapovalova; Jennifer Russell; Masakatsu Eguchi; Diana Golubeva; Monica Graham; Anargyros Xenocostas; Michael R Trus; Ronan Foley; Brian Leber; Tony J Collins; Mickie Bhatia
Journal:  Cell Chem Biol       Date:  2017-06-22       Impact factor: 8.116

Review 7.  Cancer stem cells in solid tumors: an overview.

Authors:  Catherine Adell O'Brien; Antonija Kreso; John E Dick
Journal:  Semin Radiat Oncol       Date:  2009-04       Impact factor: 5.934

8.  Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.

Authors:  Kai Fu; Xin Sun; Wenxin Zheng; Eric M Wier; Andrea Hodgson; Dat Q Tran; Stéphane Richard; Fengyi Wan
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

9.  Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.

Authors:  Kai Fu; Xin Sun; Eric M Wier; Andrea Hodgson; Yue Liu; Cynthia L Sears; Fengyi Wan
Journal:  Elife       Date:  2016-07-25       Impact factor: 8.140

10.  Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor.

Authors:  Naomi Li; Stéphane Richard
Journal:  Nucleic Acids Res       Date:  2016-06-30       Impact factor: 16.971
  10 in total
  2 in total

1.  Sam68 is required for the growth and survival of nonmelanoma skin cancer.

Authors:  Kai Fu; Xin Sun; Xue Xia; Ryan P Hobbs; Yajuan Guo; Pierre A Coulombe; Fengyi Wan
Journal:  Cancer Med       Date:  2019-08-22       Impact factor: 4.452

2.  Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity.

Authors:  Aijun Qiao; Wenxia Ma; Ying Jiang; Chaoshan Han; Baolong Yan; Junlan Zhou; Gangjian Qin
Journal:  Int J Mol Sci       Date:  2022-09-29       Impact factor: 6.208
  2 in total

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