Literature DB >> 22682243

Wnt/β-catenin signaling and disease.

Hans Clevers1, Roel Nusse.   

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22682243     DOI： 10.1016/j.cell.2012.05.012

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  2000 in total

Review 1.  Regulation of Wnt signaling by protocadherins.

Authors:  Kar Men Mah; Joshua A Weiner
Journal:  Semin Cell Dev Biol       Date:  2017-08-01       Impact factor: 7.727

2.  Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling.

Authors:  Qing Chen; Yi Su; Janine Wesslowski; Anja I Hagemann; Mirana Ramialison; Joachim Wittbrodt; Steffen Scholpp; Gary Davidson
Journal:  EMBO Rep       Date:  2014-11-12       Impact factor: 8.807

3.  Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.

Authors:  Obinna N Obianom; Yong Ai; Yingjun Li; Wei Yang; Dong Guo; Hong Yang; Srilatha Sakamuru; Menghang Xia; Fengtian Xue; Yan Shu
Journal:  J Med Chem       Date:  2019-01-10       Impact factor: 7.446

4.  A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export.

Authors:  Jiaxin Sun; Shiyan Yu; Xiao Zhang; Catherine Capac; Onyedikachi Aligbe; Timothy Daudelin; Edward M Bonder; Nan Gao
Journal:  J Cell Sci       Date:  2017-05-17       Impact factor: 5.285

5.  Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.

Authors:  Wei Kan; Michael D Enos; Elgin Korkmazhan; Stefan Muennich; Dong-Hua Chen; Melissa V Gammons; Mansi Vasishtha; Mariann Bienz; Alexander R Dunn; Georgios Skiniotis; William I Weis
Journal:  Elife       Date:  2020-04-16       Impact factor: 8.140

6.  Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects.

Authors:  Elizabeth M Ellison; Melissa A Bradley-Whitman; Mark A Lovell
Journal:  J Mol Neurosci       Date:  2017-09-02       Impact factor: 3.444

7.  ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.

Authors:  E Sánchez-Tilló; O de Barrios; E Valls; D S Darling; A Castells; A Postigo
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867

8.  Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.

Authors:  Maarten P G Massink; Marijn A Créton; Francesca Spanevello; Willem M M Fennis; Marco S Cune; Sanne M C Savelberg; Isaäc J Nijman; Madelon M Maurice; Marie-José H van den Boogaard; Gijs van Haaften
Journal:  Am J Hum Genet       Date:  2015-09-17       Impact factor: 11.025

Review 9.  The emerging roles of β-arrestins in fibrotic diseases.

Authors:  Yuan-jing Gu; Wu-yi Sun; Sen Zhang; Jing-jing Wu; Wei Wei
Journal:  Acta Pharmacol Sin       Date:  2015-09-21       Impact factor: 6.150

10.  Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.

Authors:  Lucy J Dawes; Yuki Sugiyama; Ana S Tanedo; Frank J Lovicu; John W McAvoy
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-03-01       Impact factor: 4.799
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