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Literature DB >> 24981364

Can we safely target the WNT pathway?

Abstract

WNT-β-catenin signalling is involved in a multitude of developmental processes and the maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation, migration, genetic stability and apoptosis, as well as by maintaining adult stem cells in a pluripotent state. Not surprisingly, aberrant regulation of this pathway is therefore associated with a variety of diseases, including cancer, fibrosis and neurodegeneration. Despite this knowledge, therapeutic agents specifically targeting the WNT pathway have only recently entered clinical trials and none has yet been approved. This Review examines the problems and potential solutions to this vexing situation and attempts to bring them into perspective.

Entities: Disease Gene

Mesh：

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Year: 2014 PMID： 24981364 PMCID： PMC4426976 DOI： 10.1038/nrd4233

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

292 in total

Review 1. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.

Authors: Michael T Veeman; Jeffrey D Axelrod; Randall T Moon
Journal: Dev Cell Date: 2003-09 Impact factor: 12.270

2. Symmetric division versus asymmetric division: a tale of two coactivators.

Authors: Michael Kahn
Journal: Future Med Chem Date: 2011-10 Impact factor: 3.808

3. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling.

Authors: S Dihlmann; A Siermann; M von Knebel Doeberitz
Journal: Oncogene Date: 2001-02-01 Impact factor: 9.867

4. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.

Authors: Marco Chilosi; Venerino Poletti; Alberto Zamò; Maurizio Lestani; Licia Montagna; Paola Piccoli; Serena Pedron; Manuela Bertaso; Aldo Scarpa; Bruno Murer; Alessandra Cancellieri; Roberta Maestro; Gianpietro Semenzato; Claudio Doglioni
Journal: Am J Pathol Date: 2003-05 Impact factor: 4.307

Review 5. Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways.

Authors: Tomoyo Sakata; James K Chen
Journal: Chem Soc Rev Date: 2011-04-19 Impact factor: 54.564

6. The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages.

Authors: Cynthia Mills Schumann; Julia Hamstra; Beth L Goodlin-Jones; Linda J Lotspeich; Hower Kwon; Michael H Buonocore; Cathy R Lammers; Allan L Reiss; David G Amaral
Journal: J Neurosci Date: 2004-07-14 Impact factor: 6.167

7. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors: R Nusse; H E Varmus
Journal: Cell Date: 1982-11 Impact factor: 41.582

8. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis.

Authors: Chikara Kokubu; Ulrich Heinzmann; Tomoko Kokubu; Norio Sakai; Takuo Kubota; Masanobu Kawai; Matthias B Wahl; Juan Galceran; Rudolf Grosschedl; Keiichi Ozono; Kenji Imai
Journal: Development Date: 2004-10-06 Impact factor: 6.868

9. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis.

Authors: X Li; V Placencio; J M Iturregui; C Uwamariya; A-R Sharif-Afshar; T Koyama; S W Hayward; N A Bhowmick
Journal: Oncogene Date: 2008-08-25 Impact factor: 9.867

Review 10. Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.

Authors: Wilson M Clements; Andrew M Lowy; Joanna Groden
Journal: Clin Colorectal Cancer Date: 2003-08 Impact factor: 4.481

383 in total

Review 1. Development of anticancer agents targeting the Wnt/β-catenin signaling.

Authors: Xiangqian Zhang; Jijun Hao
Journal: Am J Cancer Res Date: 2015-07-15 Impact factor: 6.166

Review 2. New therapeutic strategies for BRAF mutant colorectal cancers.

Authors: Ryan B Corcoran
Journal: J Gastrointest Oncol Date: 2015-12

Review 3. Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.

Authors: Shilong Zheng; Jiawang Liu; Yanyuan Wu; Tien L Huang; Guangdi Wang
Journal: Future Med Chem Date: 2015-12-16 Impact factor: 3.808

Review 4. The Wnt signaling pathway in cancer.

Authors: Yann Duchartre; Yong-Mi Kim; Michael Kahn
Journal: Crit Rev Oncol Hematol Date: 2015-12-24 Impact factor: 6.312

Review 5. Canonical Wnt signaling in systemic sclerosis.

Authors: Christina Bergmann; Jörg H W Distler
Journal: Lab Invest Date: 2016-01-11 Impact factor: 5.662

Review 6. Progress and renewal in gustation: new insights into taste bud development.

Authors: Linda A Barlow
Journal: Development Date: 2015-11-01 Impact factor: 6.868

7. Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.

Authors: Shanthi Ganesh; Martin L Koser; Wendy A Cyr; Girish R Chopda; Junyan Tao; Xue Shui; Bo Ying; Dongyu Chen; Purva Pandya; Edmond Chipumuro; Zakir Siddiquee; Kevin Craig; Chengjung Lai; Henryk Dudek; Satdarshan P Monga; Weimin Wang; Bob D Brown; Marc T Abrams
Journal: Mol Cancer Ther Date: 2016-07-07 Impact factor: 6.261

8. Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model.

Authors: Sean J Miller; Jenna C Glatzer; Yi-Chun Hsieh; Jeffrey D Rothstein
Journal: J Neurogenet Date: 2018-11-06 Impact factor: 1.250

9. Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice.

Authors: Obinna N Obianom; Yong Ai; Yingjun Li; Wei Yang; Dong Guo; Hong Yang; Srilatha Sakamuru; Menghang Xia; Fengtian Xue; Yan Shu
Journal: J Med Chem Date: 2019-01-10 Impact factor: 7.446

10. Cholangiocarcinoma, gone without the Wnt?

Authors: Anne Tr Noll; Thorsten Cramer; Steven Wm Olde Damink; Frank G Schaap
Journal: World J Hepatol Date: 2016-09-18