| Literature DB >> 28698676 |
Jian Ma1, Hui Lei1, Xiu Chen2, Xiaoxu Bi1, Yi Jiang2, Li Han1, Xueshi Huang1.
Abstract
Three new metabolites (2-4), together with one known compound, GTRI-02, (1) were isolated from a fermentation broth of Streptomyces violaceoruber derived from Equus burchelli feces. The structures of the new compounds 2-4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR and MS data. The anti-inflammatory activity of compounds 1-4 was tested by examining their ability to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Compound 2 showed a moderate inhibition of NO production with IC50 value of 51.2 μm.Entities:
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Year: 2017 PMID： 28698676 DOI： 10.1038/ja.2017.75
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649