Literature DB >> 28675122

MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer.

Yuzhou Wang1, Yijin Zhou1, Zhicheng Yang1, Baoying Chen1, Wennan Huang1, Yongyuan Liu1, Ying Zhang1.   

Abstract

Long non-coding RNAs recently were identified as key mediators of cancer metastasis. This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. MALAT1 promoted cancer cell invasion through inducing epithelial-mesenchymal transition. Interestingly, we revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.

Entities:  

Keywords:  MALAT1; ZEB2; epithelial–mesenchymal transition; miR-204

Mesh：

Substances：

Year:  2017        PMID： 28675122     DOI： 10.1177/1010428317690998

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  15 in total

1.  Long non-coding RNA CASC9/microRNA-590-3p axis participates in lutein-mediated suppression of breast cancer cell proliferation.

Authors:  Yuxia Zhang; Jingzhi Chang; Weiwei Jiang; Xin Ye; Shanfeng Zhang
Journal:  Oncol Lett       Date:  2021-05-20       Impact factor: 2.967

2.  The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis.

Authors:  Tian Tian; Meng Wang; Shuai Lin; Yan Guo; Zhiming Dai; Kang Liu; Pengtao Yang; Cong Dai; Yuyao Zhu; Yi Zheng; Peng Xu; Wenge Zhu; Zhijun Dai
Journal:  Mol Ther Nucleic Acids       Date:  2018-07-03       Impact factor: 8.886

Review 3.  MALAT1: a potential biomarker in cancer.

Authors:  Zhi-Xing Li; Qiong-Ni Zhu; Hai-Bo Zhang; Yang Hu; Guo Wang; Yuan-Shan Zhu
Journal:  Cancer Manag Res       Date:  2018-12-06       Impact factor: 3.989

4.  Clinicopathological and prognostic significance of zinc finger antisense 1 overexpression in cancers: A meta-analysis.

Authors:  Yuanxiu Leng; Qing Luo; Xumei Chen; Fang Chen; Xue Wang; Yana Pan
Journal:  Medicine (Baltimore)       Date:  2018-12       Impact factor: 1.817

5.  Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.

Authors:  Rong Xie; Jing Tang; Xianmin Zhu; Hui Jiang
Journal:  Biosci Rep       Date:  2019-05-17       Impact factor: 3.840

6.  Comprehensive analysis of the lncRNA‑associated competing endogenous RNA network in breast cancer.

Authors:  Jing-Jing Wang; Yue-Qing Huang; Wei Song; Yi-Fan Li; Han Wang; Wen-Jie Wang; Min Huang
Journal:  Oncol Rep       Date:  2019-10-15       Impact factor: 3.906

7.  Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells.

Authors:  Vera Mayo; Annie C Bowles; Laura E Wubker; Ismael Ortiz; Albert M Cordoves; Richard J Cote; Diego Correa; Ashutosh Agarwal
Journal:  Exp Biol Med (Maywood)       Date:  2020-11-19

8.  LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer.

Authors:  Wenyan Zhao; Donghua Geng; Shuqiang Li; Zhaofu Chen; Ming Sun
Journal:  Cancer Med       Date:  2018-02-23       Impact factor: 4.452

9.  Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer.

Authors:  Vahid Kholghi Oskooei; Lobat Geranpayeh; Mir Davood Omrani; Soudeh Ghafouri-Fard
Journal:  Cancer Manag Res       Date:  2018-09-12       Impact factor: 3.989

10.  MiR-454-3p and miR-374b-5p suppress migration and invasion of bladder cancer cells through targetting ZEB2.

Authors:  Suogang Wang; Geng Zhang; Wanxiang Zheng; Qin Xue; Di Wei; Yu Zheng; Jianlin Yuan
Journal:  Biosci Rep       Date:  2018-12-07       Impact factor: 3.840
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