J Remon1, D Isla2, P Garrido3, J de Castro4, M Majem5, N Viñolas6, A Artal7, E Carcereny8, M R García-Campelo9, P Lianes10, M Provencio11, O Juan12, P Diz13, R Blanco14, R Lopez-Castro15, I Maestu16, C Vadell17, E Felip18. 1. Medical Oncology Department, Hospital Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain. 2. Medical Oncology Department, Instituto de Investigación Sanitaria Aragón, Hospital Clinico Universitario Lozano Blesa, Saragossa, Spain. 3. Medical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain. 4. Medical Oncology Department, Hospital La Paz, Madrid, Spain. 5. Medical Oncology Department, Hospital Sant Pau, Barcelona, Spain. 6. Medical Oncology Department, Hospital Clínic, Barcelona, Spain. 7. Medical Oncology Department, Hospital Universitario Miguel Servet, Saragossa, Spain. 8. Medical Oncology Department, Hospital Germans Trias i Pujol ICO-Badalona, Barcelona, Spain. 9. Medical Oncology Department, Complexo Hospitalario Universitatio A Coruña, Coruña, Spain. 10. Medical Oncology Department, Hospital de Mataró, Mataró, Barcelona, Spain. 11. Medical Oncology Department, Hospital Puerta de Hierro, Madrid, Spain. 12. Medical Oncology Department, Hospital Universitari Politècnic La Fe, Valencia, Spain. 13. Medical Oncology Department, Hospital de León, León, Spain. 14. Medical Oncology Department, Consorci Sanitari de Terrassa, Hospital de Terrassa, Terrassa, Barcelona, Spain. 15. Medical Oncology Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. 16. Medical Oncology Department, Hospital Universitario Doctor Peset, Valencia, Spain. 17. Medical Oncology Department, Hospital de Manacor, Menorca, Spain. 18. Medical Oncology Department, Hospital Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain. efelip@vhio.net.
Abstract
BACKGROUND: The WORLD07 project is a female specific database to assess the characteristics of women with lung cancer. METHODS: WORLD07 database sets up in 2007, and prospectively stores clinical characteristics, treatment, outcome, and follow-up of lung cancer women. All women with epidermal growth factor receptor (EGFR) mutation non-small cell lung cancer (NSCLC) were selected for this analysis. RESULTS: From October 2007 to December 2012, a total of 1775 NSCLC women were recruited. EGFR mutation was identified in 34.4% of patients. Upfront EGFR tyrosine kinase inhibitor (TKI) reported a response rate of 60%, a median progression-free survival of 11.7 months, and median overall survival of 23.0 months. EGFR TKI, EGFR-mutation type, and smoking status did not impact in the outcome of treated women. CONCLUSION: Prevalence of EGFR mutation in women with NSCLC is higher than overall population with NSCLC. Efficacy of EGFR TKI in this real-world setting is similar to that previously reported.
BACKGROUND: The WORLD07 project is a female specific database to assess the characteristics of women with lung cancer. METHODS: WORLD07 database sets up in 2007, and prospectively stores clinical characteristics, treatment, outcome, and follow-up of lung cancerwomen. All women with epidermal growth factor receptor (EGFR) mutation non-small cell lung cancer (NSCLC) were selected for this analysis. RESULTS: From October 2007 to December 2012, a total of 1775 NSCLCwomen were recruited. EGFR mutation was identified in 34.4% of patients. Upfront EGFR tyrosine kinase inhibitor (TKI) reported a response rate of 60%, a median progression-free survival of 11.7 months, and median overall survival of 23.0 months. EGFR TKI, EGFR-mutation type, and smoking status did not impact in the outcome of treated women. CONCLUSION: Prevalence of EGFR mutation in women with NSCLC is higher than overall population with NSCLC. Efficacy of EGFR TKI in this real-world setting is similar to that previously reported.
Entities:
Keywords:
Advanced; EGFR mutant; NSCLC; TKI; Women
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