Dolores Isla1, Enriqueta Felip2, Nuria Viñolas3, Mariano Provencio4, Margarita Majem5, Angel Artal6, Isabel Bover7, Pilar Lianes8, Ramón DE Las Peñas9, Silvia Catot10, Javier DE Castro11, Ana Blasco12, Josefa Terrasa13, José Luis Gonzalez-Larriba14, Oscar Juan15, Manuel Dómine16, Reyes Bernabe17, Pilar Garrido18. 1. Medical Oncology Department, Instituto de Investigación Sanitaria Aragón, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain lola.isla@gmail.com. 2. Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain. 3. Medical Oncology Department, Hospital Vall d'Hebron, Barcelona, Spain. 4. Medical Oncology Department, Hospital Clínic, Barcelona, Spain. 5. Medical Oncology Department, Hospital Puerta de Hierro, Madrid, Spain. 6. Medical Oncology Department, Hospital Sant Pau, Barcelona, Spain. 7. Medical Oncology Department, Hospital Son Llátzer, Palma de Mallorca, Spain. 8. Medical Oncology Department, Hospital de Mararó, Barcelona, Spain. 9. Medical Oncology Department, Consorcio Hospital Provincial de Castellón, Castellón De La Plana, Spain. 10. Medical Oncology Department, Althaia Xarxa Assistencial Universitaria de Manresa, Manresa, Spain. 11. Medical Oncology Department, Hospital La Paz, Madrid, Spain. 12. Medical Oncology Department, Hospital General de Valencia, Valencia, Spain. 13. Medical Oncology Department, Hospital Son Espases, Palma de Mallorca, Spain. 14. Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain. 15. Medical Oncology Department, Hospital La Fe, Valencia, Spain. 16. Medical Oncology Department, Fundación Jiménez Díaz, Madrid, Spain. 17. Medical Oncology Department, Hospital Nuestra Señora de Valme, Sevilla, Spain. 18. Medical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain.
Abstract
BACKGROUND: The WORLD07 project is a female-specific database to prospectively analyze the characteristics of Spanish women with lung cancer. PATIENTS AND METHODS: We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer. RESULTS: Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p<0.001) and lung cancer (r=-0.176; p<0.001). Longer median overall survival was observed in women with a family history of cancer and lung cancer. CONCLUSION: Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking. Copyright
BACKGROUND: The WORLD07 project is a female-specific database to prospectively analyze the characteristics of Spanish women with lung cancer. PATIENTS AND METHODS: We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer. RESULTS: Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p<0.001) and lung cancer (r=-0.176; p<0.001). Longer median overall survival was observed in women with a family history of cancer and lung cancer. CONCLUSION: Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking. Copyright
Authors: Kayla R Getz; Laura S Rozek; Lisa A Peterson; Emily L Bellile; Jeremy M G Taylor; Gregory T Wolf; Alison M Mondul Journal: Laryngoscope Date: 2017-03-07 Impact factor: 3.325
Authors: J Remon; D Isla; P Garrido; J de Castro; M Majem; N Viñolas; A Artal; E Carcereny; M R García-Campelo; P Lianes; M Provencio; O Juan; P Diz; R Blanco; R Lopez-Castro; I Maestu; C Vadell; E Felip Journal: Clin Transl Oncol Date: 2017-06-28 Impact factor: 3.405