Literature DB >> 28653241

Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde-Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging.

Fang Xie1, Fangyu Peng2,3,4.   

Abstract

Copper 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

Entities:  

Keywords:  Anticancer copper complex; Green fluorescent protein, fluorescent imaging; Prostate cancer

Mesh：

Substances：

Year:  2017        PMID： 28653241     DOI： 10.1007/s10895-017-2133-z

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  14 in total

1.  A mechanism-based in vitro anticancer drug screening approach for phenolic phytochemicals.

Authors:  Stephen Hsu; Fu-Xin X Yu; Qin Huang; Jill Lewis; Baldev Singh; Douglas Dickinson; James Borke; Mohamed Sharawy; John Wataha; Tetsuya Yamamoto; Tokio Osaki; George Schuster
Journal:  Assay Drug Dev Technol       Date:  2003-10       Impact factor: 1.738

Review 2.  Advances in copper complexes as anticancer agents.

Authors:  Carlo Santini; Maura Pellei; Valentina Gandin; Marina Porchia; Francesco Tisato; Cristina Marzano
Journal:  Chem Rev       Date:  2013-10-08       Impact factor: 60.622

3.  Anti-prostate-specific membrane antigen liposomes loaded with 225Ac for potential targeted antivascular α-particle therapy of cancer.

Authors:  Amey Bandekar; Charles Zhu; Rohit Jindal; Frank Bruchertseifer; Alfred Morgenstern; Stavroula Sofou
Journal:  J Nucl Med       Date:  2013-12-12       Impact factor: 10.057

4.  Detection of a decrease in green fluorescent protein fluorescence for the monitoring of cell death: an assay amenable to high-throughput screening technologies.

Authors:  A M Steff; M Fortin; C Arguin; P Hugo
Journal:  Cytometry       Date:  2001-12-01

5.  Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes.

Authors:  K E Sandman; S S Marla; G Zlokarnik; S J Lippard
Journal:  Chem Biol       Date:  1999-08

Review 6.  Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis.

Authors:  Di Chen; Fangyu Peng; Qiuzhi Cindy Cui; Kenyon G Daniel; Shirley Orlu; Jianguo Liu; Q Ping Dou
Journal:  Front Biosci       Date:  2005-09-01

7.  Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.

Authors:  Shreelekha Adsule; Vivek Barve; Di Chen; Fakhara Ahmed; Q Ping Dou; Subhash Padhye; Fazlul H Sarkar
Journal:  J Med Chem       Date:  2006-11-30       Impact factor: 7.446

8.  Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells.

Authors:  Haiyuan Zhang; Ronald Thomas; David Oupicky; Fangyu Peng
Journal:  J Biol Inorg Chem       Date:  2007-10-02       Impact factor: 3.358

9.  Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells.

Authors:  Huawei Cai; Fangyu Peng
Journal:  Oncol Rep       Date:  2013-04-29       Impact factor: 3.906

Review 10.  Application of GFP imaging in cancer.

Authors:  Robert M Hoffman
Journal:  Lab Invest       Date:  2015-02-16       Impact factor: 5.662
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  4 in total

1.  Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging.

Authors:  Fang Xie; Huawei Cai; Fangyu Peng
Journal:  J Biol Inorg Chem       Date:  2018-07-13       Impact factor: 3.358

2.  Anticancer Activity of Copper Complex of (4R)-(-)-2-Thioxo-4-thiazolidinecarboxylic Acid and 3-Rhodaninepropionic Acid on Prostate and Breast Cancer Cells by Fluorescent Microscopic Imaging.

Authors:  Fang Xie; Fangyu Peng
Journal:  J Fluoresc       Date:  2017-09-09       Impact factor: 2.217

Review 3.  Harnessing the Power of Optical Microscopic and Macroscopic Imaging for Natural Products as Cancer Therapeutics.

Authors:  Tianyu Yan; Qi Zeng; Lin Wang; Nan Wang; Honghao Cao; Xinyi Xu; Xueli Chen
Journal:  Front Pharmacol       Date:  2019-11-28       Impact factor: 5.810

Review 4.  Copper signalling: causes and consequences.

Authors:  Julianna Kardos; László Héja; Ágnes Simon; István Jablonkai; Richard Kovács; Katalin Jemnitz
Journal:  Cell Commun Signal       Date:  2018-10-22       Impact factor: 5.712
  4 in total

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