Literature DB >> 17125278

Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.

Shreelekha Adsule1, Vivek Barve, Di Chen, Fakhara Ahmed, Q Ping Dou, Subhash Padhye, Fazlul H Sarkar.   

Abstract

We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-137) was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 microM), supporting the novelty of 2.

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Year:  2006        PMID： 17125278     DOI： 10.1021/jm060712l

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  39 in total

1.  Turning tumor-promoting copper into an anti-cancer weapon via high-throughput chemistry.

Authors:  F Wang; P Jiao; M Qi; M Frezza; Q P Dou; B Yan
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

2.  A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells.

Authors:  Fei Wang; Shumei Zhai; Xiaojun Liu; Liwen Li; Shirley Wu; Q Ping Dou; Bing Yan
Journal:  Cancer Lett       Date:  2010-10-29       Impact factor: 8.679

3.  Highly Selective and Efficient Synthesis of 7-Aminoquinolines and Their Applications as Golgi-Localized Probes.

Authors:  Jiahui Chen; Huijing Liu; Li Yang; Jun Jiang; Guoqiang Bi; Guoqing Zhang; Guisheng Li; Xiaofeng Chen
Journal:  ACS Med Chem Lett       Date:  2019-05-28       Impact factor: 4.345

4.  The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells.

Authors:  Saverio Tardito; Claudio Isella; Enzo Medico; Luciano Marchiò; Elena Bevilacqua; Maria Hatzoglou; Ovidio Bussolati; Renata Franchi-Gazzola
Journal:  J Biol Chem       Date:  2009-06-26       Impact factor: 5.157

5.  Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes.

Authors:  Jian Zuo; Caifeng Bi; Yuhua Fan; Daniela Buac; Chiara Nardon; Kenyon G Daniel; Q Ping Dou
Journal:  J Inorg Biochem       Date:  2012-10-15       Impact factor: 4.155

6.  Fundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculations.

Authors:  Donghui Wei; Lei Fang; Mingsheng Tang; Chang-Guo Zhan
Journal:  J Phys Chem B       Date:  2013-10-10       Impact factor: 2.991

7.  Organic cadmium complexes as proteasome inhibitors and apoptosis inducers in human breast cancer cells.

Authors:  Zhen Zhang; Caifeng Bi; Daniela Buac; Yuhua Fan; Xia Zhang; Jian Zuo; Pengfei Zhang; Nan Zhang; Lili Dong; Q Ping Dou
Journal:  J Inorg Biochem       Date:  2013-02-21       Impact factor: 4.155

8.  2-(4-Phenyl-3H-1,5-benzodiazepin-2-yl)phenol.

Authors:  Feng-Ke Yang; Wei Cheng; Yi-Ning Ding
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-08

9.  Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells.

Authors:  Vesna Milacic; Peifu Jiao; Bin Zhang; Bing Yan; Q Ping Dou
Journal:  Int J Oncol       Date:  2009-12       Impact factor: 5.650

10.  Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors.

Authors:  Michael Frezza; Sarmad Sahiel Hindo; Dajena Tomco; Marco M Allard; Qiuzhi Cindy Cui; Mary Jane Heeg; Di Chen; Q Ping Dou; Cláudio N Verani
Journal:  Inorg Chem       Date:  2009-07-06       Impact factor: 5.165
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