Lisa Manderino1, Ian Carroll2, M Andrea Azcarate-Peril2, Amber Rochette1, Leslie Heinberg3, Christine Peat4, Kristine Steffen5, James Mitchell6, John Gunstad1. 1. 1Department of Psychological Sciences,Kent State University,Kent,Ohio. 2. 2Department of Cell Biology and Physiology and Microbiome Core Facility,UNC School of Medicine,Chapel Hill,North Carolina. 3. 3Cleveland Clinic,Lerner College of Medicine of Case Western Reserve University,Bariatric and Metabolic Institute,Cleveland,Ohio. 4. 4Center of Excellence for Eating Disorders,UNC School of Medicine,Chapel Hill,North Carolina. 5. 5Department of Pharmaceutical Sciences,College of Pharmacy,Nursing and Allied Sciences,North Dakota State University,Fargo,North Dakota. 6. 6Neuropsychiatric Research Institute;Department of Clinical Neuroscience,School of Medicine and Health Services,University of North Dakota.
Abstract
OBJECTIVES: Dysbiosis of the gut microbiome is implicated in numerous human health conditions. Animal studies have linked microbiome disruption to changes in cognitive functioning, although no study has examined this possibility in neurologically healthy older adults. METHODS: Participants were 43 community-dwelling older adults (50-85 years) that completed a brief cognitive test battery and provided stool samples for gut microbiome sequencing. Participants performing≥1 SD below normative performance on two or more tests were compared to persons with one or fewer impaired scores. RESULTS: Mann Whitney U tests revealed different distributions of Bacteroidetes (p=.01), Firmicutes (p=.02), Proteobacteria (p=.04), and Verrucomicrobia (p=.003) between Intact and Impaired groups. These phyla were significantly correlated with cognitive test performances, particularly Verrucomicrobia and attention/executive function measures. CONCLUSIONS: The current findings suggest that composition of the gut microbiome is associated with cognitive test performance in neurologically healthy older adults. Future studies are needed to confirm these findings and explore possible mechanisms. (JINS, 2017, 23, 700-705).
OBJECTIVES:Dysbiosis of the gut microbiome is implicated in numerous human health conditions. Animal studies have linked microbiome disruption to changes in cognitive functioning, although no study has examined this possibility in neurologically healthy older adults. METHODS:Participants were 43 community-dwelling older adults (50-85 years) that completed a brief cognitive test battery and provided stool samples for gut microbiome sequencing. Participants performing≥1 SD below normative performance on two or more tests were compared to persons with one or fewer impaired scores. RESULTS: Mann Whitney U tests revealed different distributions of Bacteroidetes (p=.01), Firmicutes (p=.02), Proteobacteria (p=.04), and Verrucomicrobia (p=.003) between Intact and Impaired groups. These phyla were significantly correlated with cognitive test performances, particularly Verrucomicrobia and attention/executive function measures. CONCLUSIONS: The current findings suggest that composition of the gut microbiome is associated with cognitive test performance in neurologically healthy older adults. Future studies are needed to confirm these findings and explore possible mechanisms. (JINS, 2017, 23, 700-705).
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