Literature DB >> 31454547

Obesity-related cognitive impairment: The role of endothelial dysfunction.

Joy Jones Buie1, Luke S Watson2, Crystal J Smith3, Catrina Sims-Robinson4.   

Abstract

Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  diet; gut dysbiosis; hyperinsulinemia; inflammation; insulin resistance; memory

Mesh：

Year:  2019        PMID： 31454547      PMCID： PMC6834913          DOI： 10.1016/j.nbd.2019.104580

Source DB:  PubMed          Journal:  Neurobiol Dis        ISSN： 0969-9961            Impact factor:   5.996


  398 in total

1.  Alterations to the microbiota-colon-brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice.

Authors:  Peng Zhang; Yinghua Yu; Yanfang Qin; Yuan Zhou; Renxian Tang; Qingling Wang; Xiangyang Li; Hongqin Wang; Katrina Weston-Green; Xu-Feng Huang; Kuiyang Zheng
Journal:  J Nutr Biochem       Date:  2018-09-01       Impact factor: 6.048

2.  Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial.

Authors:  Suzanne Craft; Laura D Baker; Thomas J Montine; Satoshi Minoshima; G Stennis Watson; Amy Claxton; Matthew Arbuckle; Maureen Callaghan; Elaine Tsai; Stephen R Plymate; Pattie S Green; James Leverenz; Donna Cross; Brooke Gerton
Journal:  Arch Neurol       Date:  2011-09-12

3.  Diet dominates host genotype in shaping the murine gut microbiota.

Authors:  Rachel N Carmody; Georg K Gerber; Jesus M Luevano; Daniel M Gatti; Lisa Somes; Karen L Svenson; Peter J Turnbaugh
Journal:  Cell Host Microbe       Date:  2014-12-18       Impact factor: 21.023

4.  High-intensity interval and moderate-intensity continuous training elicit similar enjoyment and adherence levels in overweight and obese adults.

Authors:  Chantal A Vella; Katrina Taylor; Devin Drummer
Journal:  Eur J Sport Sci       Date:  2017-08-09       Impact factor: 4.050

5.  Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin.

Authors:  W A Banks; J B Jaspan; W Huang; A J Kastin
Journal:  Peptides       Date:  1997       Impact factor: 3.750

6.  Frontal cortical thinning and subcortical volume reductions in early adulthood obesity.

Authors:  Idoia Marqués-Iturria; Roser Pueyo; Maite Garolera; Bàrbara Segura; Carme Junqué; Isabel García-García; María José Sender-Palacios; María Vernet-Vernet; Ana Narberhaus; Mar Ariza; María Ángeles Jurado
Journal:  Psychiatry Res       Date:  2013-09-14       Impact factor: 3.222

7.  Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet.

Authors:  Mari-Pau Mena; Emilio Sacanella; Mónica Vazquez-Agell; Mercedes Morales; Montserrat Fitó; Rosa Escoda; Manuel Serrano-Martínez; Jordi Salas-Salvadó; Neus Benages; Rosa Casas; Rosa M Lamuela-Raventós; Ferran Masanes; Emilio Ros; Ramon Estruch
Journal:  Am J Clin Nutr       Date:  2008-12-03       Impact factor: 7.045

Review 8.  Inflammation, obesity and comorbidities: the role of diet.

Authors:  Mónica Bulló; Patricia Casas-Agustench; Pilar Amigó-Correig; Javier Aranceta; Jordi Salas-Salvadó
Journal:  Public Health Nutr       Date:  2007-10       Impact factor: 4.022

9.  Rapid and reversible impairment of episodic memory by a high-fat diet in mice.

Authors:  Fiona H McLean; Christine Grant; Amanda C Morris; Graham W Horgan; Alex J Polanski; Kevin Allan; Fiona M Campbell; Rosamund F Langston; Lynda M Williams
Journal:  Sci Rep       Date:  2018-08-10       Impact factor: 4.379

10.  Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

Authors:  Stefano Tarantini; M Noa Valcarcel-Ares; Andriy Yabluchanskiy; Zsuzsanna Tucsek; Peter Hertelendy; Tamas Kiss; Tripti Gautam; Xin A Zhang; William E Sonntag; Rafael de Cabo; Eszter Farkas; Michael H Elliott; Michael T Kinter; Ferenc Deak; Zoltan Ungvari; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2018-06-14       Impact factor: 6.053
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  17 in total

Review 1.  Promoting Successful Cognitive Aging: A Ten-Year Update.

Authors:  Taylor J Krivanek; Seth A Gale; Brittany M McFeeley; Casey M Nicastri; Kirk R Daffner
Journal:  J Alzheimers Dis       Date:  2021       Impact factor: 4.472

Review 2.  Vascular Cognitive Impairment (VCI).

Authors:  Tatjana Rundek; Magdalena Tolea; Taylor Ariko; Eric A Fagerli; Christian J Camargo
Journal:  Neurotherapeutics       Date:  2021-12-22       Impact factor: 6.088

3.  Correlations Between Endocrine Hormones and Cognitive Function in Patients with Obesity: a Cross-sectional Study.

Authors:  Yiliang Zhang; Biao Huang; Wah Yang; Shuming Zhong; Shunkai Lai; Hui Zhao; Jiali He; Shujing Cai; Sihui Lv; Cunchuan Wang; Yanbin Jia
Journal:  Obes Surg       Date:  2022-04-29       Impact factor: 3.479

4.  Cognitive Function Changes in Older People. Results of Second Wave of Cognition of Older People, Education, Recreational Activities, NutritIon, Comorbidities, fUnctional Capacity Studies (COPERNICUS).

Authors:  Sławomir Kujawski; Agnieszka Kujawska; Radosław Perkowski; Joanna Androsiuk-Perkowska; Weronika Hajec; Małgorzata Kwiatkowska; Natalia Skierkowska; Jakub Husejko; Daria Bieniek; Julia L Newton; Karl J Morten; Paweł Zalewski; Kornelia Kędziora-Kornatowska
Journal:  Front Aging Neurosci       Date:  2021-05-06       Impact factor: 5.750

5.  Sex-dependent effects of forced exercise in the body composition of adolescent rats.

Authors:  Y Kutsenko; A Barreda; A Toval; D Garrigos; M Martínez-Morga; B Ribeiro Do Couto; J L Ferran
Journal:  Sci Rep       Date:  2021-05-12       Impact factor: 4.379

Review 6.  Coronavirus Disease (COVID-19) Caused by (SARS-CoV-2) Infections: A Real Challenge for Human Gut Microbiota.

Authors:  Dan-Cristian Vodnar; Laura Mitrea; Bernadette-Emoke Teleky; Katalin Szabo; Lavinia-Florina Călinoiu; Silvia-Amalia Nemeş; Gheorghe-Adrian Martău
Journal:  Front Cell Infect Microbiol       Date:  2020-12-09       Impact factor: 5.293

7.  Associations of fat mass and muscle function but not lean mass with cognitive impairment: The Yishun Study.

Authors:  Nien Xiang Tou; Shiou-Liang Wee; Benedict Wei Jun Pang; Lay Khoon Lau; Khalid Abdul Jabbar; Wei Ting Seah; Kenneth Kexun Chen; Tze Pin Ng
Journal:  PLoS One       Date:  2021-08-26       Impact factor: 3.240

Review 8.  A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders.

Authors:  Maddie Perdoncin; Alec Konrad; Joshua R Wyner; Samir Lohana; Sneha S Pillai; Duane G Pereira; Hari Vishal Lakhani; Komal Sodhi
Journal:  Front Mol Neurosci       Date:  2021-10-07       Impact factor: 6.261

9.  Inhibition of Soluble Epoxide Hydrolase Is Protective against the Multiomic Effects of a High Glycemic Diet on Brain Microvascular Inflammation and Cognitive Dysfunction.

Authors:  Saivageethi Nuthikattu; Dragan Milenkovic; Jennifer E Norman; John Rutledge; Amparo Villablanca
Journal:  Nutrients       Date:  2021-11-01       Impact factor: 5.717

10.  Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system.

Authors:  Yasuhisa Ano; Rena Ohya; Takahiro Yamazaki; Chika Takahashi; Yoshimasa Taniguchi; Keiji Kondo; Akihiko Takashima; Kazuyuki Uchida; Hiroyuki Nakayama
Journal:  Sci Rep       Date:  2020-11-18       Impact factor: 4.379
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