Literature DB >> 33337961

Obesity-induced cognitive impairment in older adults: a microvascular perspective.

Priya Balasubramanian1, Tamas Kiss1,2, Stefano Tarantini1,3,4, Ádám Nyúl-Tóth1,5, Chetan Ahire1, Andriy Yabluchanskiy1, Tamas Csipo1,3,6, Agnes Lipecz1,3, Adam Tabak3,7,8, Adam Institoris9, Anna Csiszar1,2, Zoltan Ungvari1,2,3,4.   

Abstract

Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.

Entities:  

Keywords:  aging; endothelial dysfunction; metabolic syndrome; neurovascular coupling; senescence

Mesh：

Year:  2020        PMID： 33337961      PMCID： PMC8091942          DOI： 10.1152/ajpheart.00736.2020

Source DB:  PubMed          Journal:  Am J Physiol Heart Circ Physiol        ISSN： 0363-6135            Impact factor:   4.733


  322 in total

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Journal:  Obesity (Silver Spring)       Date:  2013-05-19       Impact factor: 5.002
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