Caroline L Lassen-Greene1, Kayla Steward1, Ozioma Okonkwo2, Ellen Porter3, Michael Crowe1, David E Vance4, H Randall Griffith5, Karlene Ball1, Daniel C Marson6,7, Virginia G Wadley7,8. 1. 1 Department of Psychology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. 2. 2 Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. 3. 3 Collat School of Business, University of Alabama at Birmingham, Birmingham, AL, USA. 4. 4 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA. 5. 5 Ackerson and Associates, Vestavia Hills, AL, USA. 6. 6 Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. 7. 7 Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA. 8. 8 Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Abstract
OBJECTIVES: Research estimates that a significant percentage of individuals with mild cognitive impairment (MCI) experience functional difficulties. In addition to reduced accuracy on measures of everyday function, cross-sectional research has demonstrated that speed of performing instrumental activities of daily living (IADLs) is slowed in individuals with MCI. The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers. DESIGN: Linear mixed models were used to estimate the group differences in longitudinal performance on measures of IADLs. SETTING: Assessments were conducted at university and medical research centers. PARTICIPANTS: The sample consisted of 80 participants with MCI and 80 control participants who were enrolled in the Alzheimer's Disease Research Center's Measuring Independent Living in the Elderly Study. MEASUREMENTS: Instrumental activities of daily living speed and accuracy were directly assessed using selected domains of the Financial Capacity Instrument, the Timed IADL assessment, and driving-related assessments (Useful Field of View, Road Sign Test). RESULTS: Individuals with MCI performed worse on speed and accuracy measures of IADLs in comparison to cognitively normal peers and demonstrated significantly steeper rates of decline over three years in either speed or accuracy in all domains assessed. CONCLUSION: Both speed and accuracy of performance on measures of IADL are valuable indices for early detection of functional change in MCI. The performance pattern may reflect a trade-off between speed and accuracy that can guide clinical recommendations for maintaining patient independence.
OBJECTIVES: Research estimates that a significant percentage of individuals with mild cognitive impairment (MCI) experience functional difficulties. In addition to reduced accuracy on measures of everyday function, cross-sectional research has demonstrated that speed of performing instrumental activities of daily living (IADLs) is slowed in individuals with MCI. The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers. DESIGN: Linear mixed models were used to estimate the group differences in longitudinal performance on measures of IADLs. SETTING: Assessments were conducted at university and medical research centers. PARTICIPANTS: The sample consisted of 80 participants with MCI and 80 control participants who were enrolled in the Alzheimer's Disease Research Center's Measuring Independent Living in the Elderly Study. MEASUREMENTS: Instrumental activities of daily living speed and accuracy were directly assessed using selected domains of the Financial Capacity Instrument, the Timed IADL assessment, and driving-related assessments (Useful Field of View, Road Sign Test). RESULTS: Individuals with MCI performed worse on speed and accuracy measures of IADLs in comparison to cognitively normal peers and demonstrated significantly steeper rates of decline over three years in either speed or accuracy in all domains assessed. CONCLUSION: Both speed and accuracy of performance on measures of IADL are valuable indices for early detection of functional change in MCI. The performance pattern may reflect a trade-off between speed and accuracy that can guide clinical recommendations for maintaining patient independence.
Entities:
Keywords:
MCI; aging; instrumental activities of daily living
Authors: M H Tabert; S M Albert; L Borukhova-Milov; Y Camacho; G Pelton; X Liu; Y Stern; D P Devanand Journal: Neurology Date: 2002-03-12 Impact factor: 9.910
Authors: Sarah T Farias; Dan Mungas; Bruce R Reed; Danielle Harvey; Deborah Cahn-Weiner; Charles Decarli Journal: Alzheimer Dis Assoc Disord Date: 2006 Oct-Dec Impact factor: 2.703
Authors: Ozioma C Okonkwo; Virginia G Wadley; H Randall Griffith; Katherine Belue; Sara Lanza; Edward Y Zamrini; Lindy E Harrell; John C Brockington; David Clark; Rema Raman; Daniel C Marson Journal: Am J Geriatr Psychiatry Date: 2008-08 Impact factor: 4.105
Authors: O Okonkwo; H R Griffith; K Belue; S Lanza; E Y Zamrini; L E Harrell; J C Brockington; D Clark; R Raman; D C Marson Journal: Neurology Date: 2007-10-09 Impact factor: 9.910
Authors: Virginia G Wadley; Michael Crowe; Michael Marsiske; Sarah E Cook; Frederick W Unverzagt; Adrienne L Rosenberg; Daniel Rexroth Journal: J Am Geriatr Soc Date: 2007-08 Impact factor: 5.562
Authors: Katrin Jekel; Marinella Damian; Carina Wattmo; Lucrezia Hausner; Roger Bullock; Peter J Connelly; Bruno Dubois; Maria Eriksdotter; Michael Ewers; Elmar Graessel; Milica G Kramberger; Emma Law; Patrizia Mecocci; José L Molinuevo; Louise Nygård; Marcel Gm Olde-Rikkert; Jean-Marc Orgogozo; Florence Pasquier; Karine Peres; Eric Salmon; Sietske Am Sikkes; Tomasz Sobow; René Spiegel; Magda Tsolaki; Bengt Winblad; Lutz Frölich Journal: Alzheimers Res Ther Date: 2015-03-18 Impact factor: 6.982
Authors: Kayla A Steward; Tyler P Bull; Richard Kennedy; Michael Crowe; Virginia G Wadley Journal: Arch Clin Neuropsychol Date: 2020-05-22 Impact factor: 2.813
Authors: Virginia G Wadley; Tyler P Bull; Yue Zhang; Cheyanne Barba; R Nick Bryan; Michael Crowe; Lisa Desiderio; Georg Deutsch; Guray Erus; David S Geldmacher; Rodney Go; Caroline L Lassen-Greene; Olga A Mamaeva; Daniel C Marson; Marianne McLaughlin; Ilya M Nasrallah; Cynthia Owsley; Jesse Passler; Rodney T Perry; Giovanna Pilonieta; Kayla A Steward; Richard E Kennedy Journal: J Gerontol A Biol Sci Med Sci Date: 2021-09-13 Impact factor: 6.053