Literature DB >> 30901549

Personalized Medicine and the Power of Electronic Health Records.

Noura S Abul-Husn1, Eimear E Kenny2.   

Abstract

Personalized medicine has largely been enabled by the integration of genomic and other data with electronic health records (EHRs) in the United States and elsewhere. Increased EHR adoption across various clinical settings and the establishment of EHR-linked population-based biobanks provide unprecedented opportunities for the types of translational and implementation research that drive personalized medicine. We review advances in the digitization of health information and the proliferation of genomic research in health systems and provide insights into emerging paths for the widespread implementation of personalized medicine.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30901549      PMCID： PMC6921466          DOI： 10.1016/j.cell.2019.02.039

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  118 in total

1.  The family history--more important than ever.

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Journal:  N Engl J Med       Date:  2004-11-25       Impact factor: 91.245

2.  The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank.

Authors:  Shiu Lun Au Yeung; Shan Luo; C Mary Schooling
Journal:  Diabetes Care       Date:  2018-06-27       Impact factor: 19.112

Review 3.  Noninvasive Prenatal DNA Testing: The Vanguard of Genomic Medicine.

Authors:  Lisa Hui; Diana W Bianchi
Journal:  Annu Rev Med       Date:  2016-10-10       Impact factor: 13.739

4.  Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.

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Journal:  JAMA       Date:  2016-12-13       Impact factor: 56.272

5.  Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing.

Authors:  Joshua W Knowles; Daniel J Rader; Muin J Khoury
Journal:  JAMA       Date:  2017-07-25       Impact factor: 56.272

6.  Deep Phenotyping on Electronic Health Records Facilitates Genetic Diagnosis by Clinical Exomes.

Authors:  Jung Hoon Son; Gangcai Xie; Chi Yuan; Lyudmila Ena; Ziran Li; Andrew Goldstein; Lulin Huang; Liwei Wang; Feichen Shen; Hongfang Liu; Karla Mehl; Emily E Groopman; Maddalena Marasa; Krzysztof Kiryluk; Ali G Gharavi; Wendy K Chung; George Hripcsak; Carol Friedman; Chunhua Weng; Kai Wang
Journal:  Am J Hum Genet       Date:  2018-06-28       Impact factor: 11.025

7.  Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants.

Authors:  Adam H Buchanan; Kandamurugu Manickam; Michelle N Meyer; Jennifer K Wagner; Miranda L G Hallquist; Janet L Williams; Alanna Kulchak Rahm; Marc S Williams; Zong-Ming E Chen; Chaitali K Shah; Tullika K Garg; Amanda L Lazzeri; Marci L B Schwartz; D'Andra M Lindbuchler; Audrey L Fan; Rosemary Leeming; Pedro O Servano; Ashlee L Smith; Victor G Vogel; Noura S Abul-Husn; Frederick E Dewey; Matthew S Lebo; Heather M Mason-Suares; Marylyn D Ritchie; F Daniel Davis; David J Carey; David T Feinberg; W Andrew Faucett; David H Ledbetter; Michael F Murray
Journal:  Genet Med       Date:  2017-10-26       Impact factor: 8.822

8.  Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Authors:  Nathan O Stitziel; Kathleen E Stirrups; Nicholas G D Masca; Jeanette Erdmann; Paola G Ferrario; Inke R König; Peter E Weeke; Thomas R Webb; Paul L Auer; Ursula M Schick; Yingchang Lu; He Zhang; Marie-Pierre Dube; Anuj Goel; Martin Farrall; Gina M Peloso; Hong-Hee Won; Ron Do; Erik van Iperen; Stavroula Kanoni; Jochen Kruppa; Anubha Mahajan; Robert A Scott; Christina Willenberg; Peter S Braund; Julian C van Capelleveen; Alex S F Doney; Louise A Donnelly; Rosanna Asselta; Piera A Merlini; Stefano Duga; Nicola Marziliano; Josh C Denny; Christian M Shaffer; Nour Eddine El-Mokhtari; Andre Franke; Omri Gottesman; Stefanie Heilmann; Christian Hengstenberg; Per Hoffman; Oddgeir L Holmen; Kristian Hveem; Jan-Håkan Jansson; Karl-Heinz Jöckel; Thorsten Kessler; Jennifer Kriebel; Karl L Laugwitz; Eirini Marouli; Nicola Martinelli; Mark I McCarthy; Natalie R Van Zuydam; Christa Meisinger; Tõnu Esko; Evelin Mihailov; Stefan A Escher; Maris Alver; Susanne Moebus; Andrew D Morris; Martina Müller-Nurasyid; Majid Nikpay; Oliviero Olivieri; Louis-Philippe Lemieux Perreault; Alaa AlQarawi; Neil R Robertson; Karen O Akinsanya; Dermot F Reilly; Thomas F Vogt; Wu Yin; Folkert W Asselbergs; Charles Kooperberg; Rebecca D Jackson; Eli Stahl; Konstantin Strauch; Tibor V Varga; Melanie Waldenberger; Lingyao Zeng; Aldi T Kraja; Chunyu Liu; George B Ehret; Christopher Newton-Cheh; Daniel I Chasman; Rajiv Chowdhury; Marco Ferrario; Ian Ford; J Wouter Jukema; Frank Kee; Kari Kuulasmaa; Børge G Nordestgaard; Markus Perola; Danish Saleheen; Naveed Sattar; Praveen Surendran; David Tregouet; Robin Young; Joanna M M Howson; Adam S Butterworth; John Danesh; Diego Ardissino; Erwin P Bottinger; Raimund Erbel; Paul W Franks; Domenico Girelli; Alistair S Hall; G Kees Hovingh; Adnan Kastrati; Wolfgang Lieb; Thomas Meitinger; William E Kraus; Svati H Shah; Ruth McPherson; Marju Orho-Melander; Olle Melander; Andres Metspalu; Colin N A Palmer; Annette Peters; Daniel Rader; Muredach P Reilly; Ruth J F Loos; Alex P Reiner; Dan M Roden; Jean-Claude Tardif; John R Thompson; Nicholas J Wareham; Hugh Watkins; Cristen J Willer; Sekkar Kathiresan; Panos Deloukas; Nilesh J Samani; Heribert Schunkert
Journal:  N Engl J Med       Date:  2016-03-02       Impact factor: 91.245

9.  ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

Authors:  Robert C Green; Jonathan S Berg; Wayne W Grody; Sarah S Kalia; Bruce R Korf; Christa L Martin; Amy L McGuire; Robert L Nussbaum; Julianne M O'Daniel; Kelly E Ormond; Heidi L Rehm; Michael S Watson; Marc S Williams; Leslie G Biesecker
Journal:  Genet Med       Date:  2013-06-20       Impact factor: 8.822

Review 10.  Implementation and utilization of genetic testing in personalized medicine.

Authors:  Noura S Abul-Husn; Aniwaa Owusu Obeng; Saskia C Sanderson; Omri Gottesman; Stuart A Scott
Journal:  Pharmgenomics Pers Med       Date:  2014-08-13
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  44 in total

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2.  Evaluating risk for alcohol use disorder: Polygenic risk scores and family history.

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3.  Leveraging health systems data to characterize a large effect variant conferring risk for liver disease in Puerto Ricans.

Authors:  Gillian M Belbin; Stephanie Rutledge; Tetyana Dodatko; Sinead Cullina; Michael C Turchin; Sumita Kohli; Denis Torre; Muh-Ching Yee; Christopher R Gignoux; Noura S Abul-Husn; Sander M Houten; Eimear E Kenny
Journal:  Am J Hum Genet       Date:  2021-10-21       Impact factor: 11.025

Review 4.  Advances in the Genetics and Genomics of Heart Failure.

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Review 5.  Long overdue: including adults with brain disorders in precision health initiatives.

Authors:  Brenda M Finucane; Scott M Myers; Christa L Martin; David H Ledbetter
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Review 6.  A brief history of human disease genetics.

Authors:  Melina Claussnitzer; Judy H Cho; Rory Collins; Nancy J Cox; Emmanouil T Dermitzakis; Matthew E Hurles; Sekar Kathiresan; Eimear E Kenny; Cecilia M Lindgren; Daniel G MacArthur; Kathryn N North; Sharon E Plon; Heidi L Rehm; Neil Risch; Charles N Rotimi; Jay Shendure; Nicole Soranzo; Mark I McCarthy
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7.  Adolescent perceptions of pharmacogenetic testing.

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8.  Single Cell Technologies to Dissect Heterogenous Immune Cell Therapy Products.

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9.  Expanding the Vision of Quality and Safety in Genomic Medicine.

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Review 10.  Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes.

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