| Literature DB >> 27197191 |
Gordon Fehringer1, Peter Kraft2, Paul D Pharoah3, Rosalind A Eeles4, Nilanjan Chatterjee5, Fredrick R Schumacher6, Joellen M Schildkraut7, Sara Lindström2, Paul Brennan8, Heike Bickeböller9, Richard S Houlston4, Maria Teresa Landi5, Neil Caporaso5, Angela Risch10, Ali Amin Al Olama11, Sonja I Berndt5, Edward L Giovannucci2, Henrik Grönberg12, Zsofia Kote-Jarai4, Jing Ma13, Kenneth Muir14, Meir J Stampfer15, Victoria L Stevens16, Fredrik Wiklund12, Walter C Willett2, Ellen L Goode17, Jennifer B Permuth18, Harvey A Risch19, Brett M Reid18, Stephane Bezieau20, Hermann Brenner21, Andrew T Chan22, Jenny Chang-Claude23, Thomas J Hudson24, Jonathan K Kocarnik25, Polly A Newcomb25, Robert E Schoen26, Martha L Slattery27, Emily White25, Muriel A Adank28, Habibul Ahsan29, Kristiina Aittomäki30, Laura Baglietto31, Carl Blomquist30, Federico Canzian32, Kamila Czene12, Isabel Dos-Santos-Silva33, A Heather Eliassen34, Jonine D Figueroa5, Dieter Flesch-Janys35, Olivia Fletcher36, Montserrat Garcia-Closas5, Mia M Gaudet16, Nichola Johnson36, Per Hall12, Aditi Hazra15, Rebecca Hein37, Albert Hofman38, John L Hopper39, Astrid Irwanto40, Mattias Johansson41, Rudolf Kaaks23, Muhammad G Kibriya29, Peter Lichtner42, Jianjun Liu40, Eiliv Lund43, Enes Makalic39, Alfons Meindl44, Bertram Müller-Myhsok45, Taru A Muranen30, Heli Nevanlinna30, Petra H Peeters46, Julian Peto33, Ross L Prentice25, Nazneen Rahman47, Maria Jose Sanchez48, Daniel F Schmidt39, Rita K Schmutzler49, Melissa C Southey31, Rulla Tamimi15, Ruth C Travis50, Clare Turnbull47, Andre G Uitterlinden51, Zhaoming Wang5, Alice S Whittemore52, Xiaohong R Yang5, Wei Zheng53, Daniel D Buchanan31, Graham Casey6, David V Conti6, Christopher K Edlund6, Steven Gallinger1, Robert W Haile52, Mark Jenkins31, Loïc Le Marchand54, Li Li55, Noralene M Lindor56, Stephanie L Schmit6, Stephen N Thibodeau17, Michael O Woods57, Thorunn Rafnar58, Julius Gudmundsson58, Simon N Stacey58, Kari Stefansson58, Patrick Sulem58, Y Ann Chen18, Jonathan P Tyrer3, David C Christiani2, Yongyue Wei2, Hongbing Shen59, Zhibin Hu59, Xiao-Ou Shu53, Kouya Shiraishi60, Atsushi Takahashi61, Yohan Bossé62, Ma'en Obeidat63, David Nickle64, Wim Timens65, Matthew L Freedman66, Qiyuan Li67, Daniela Seminara5, Stephen J Chanock5, Jian Gong25, Ulrike Peters25, Stephen B Gruber6, Christopher I Amos68, Thomas A Sellers18, Douglas F Easton3, David J Hunter2, Christopher A Haiman6, Brian E Henderson6, Rayjean J Hung69.
Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR. ©2016 American Association for Cancer Research.Entities:
Mesh：
Year: 2016 PMID： 27197191 PMCID： PMC5010493 DOI： 10.1158/0008-5472.CAN-15-2980
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701