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Literature DB >> 28634412

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets.

Abstract

Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2017 PMID： 28634412 PMCID： PMC6380505 DOI： 10.1038/nrgastro.2017.71

Source DB: PubMed Journal: Nat Rev Gastroenterol Hepatol ISSN： 1759-5045 Impact factor: 46.802

112 in total

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100 in total

Review 1. Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications.

Authors: Young-Eun Cho; Byoung-Joon Song; Mohammed Akbar; Moon-Chang Baek
Journal: Pharmacol Ther Date: 2018-04-03 Impact factor: 12.310

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Journal: Cell Mol Life Sci Date: 2021-04-05 Impact factor: 9.261

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Journal: J Hepatol Date: 2019-02 Impact factor: 25.083

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Journal: Hepatology Date: 2018-05-02 Impact factor: 17.425

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Authors: Harmeet Malhi
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2019-09-23 Impact factor: 4.052

7. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90.

Authors: Banishree Saha; Fatemeh Momen-Heravi; Istvan Furi; Karen Kodys; Donna Catalano; Anwesha Gangopadhyay; Reka Haraszti; Abhishek Satishchandran; Arvin Iracheta-Vellve; Adeyinka Adejumo; Scott A Shaffer; Gyongyi Szabo
Journal: Hepatology Date: 2018-04-06 Impact factor: 17.425